Please use this identifier to cite or link to this item:
10.1007/s10787-022-00925-z
Title: | Selenium, selenoprotein P, and oxidative stress levels in SARS-CoV-2 patients during illness and recovery |
Authors: | Skesters, A. Kustovs, D. Lece, A. Moreino, E. Petrosina, E. Rainsford, K. D. Scientific Laboratory of Biochemistry Statistics Unit |
Keywords: | COVID-19;Free radicals;Oxidative stress;Selenium;Selenoprotein P;3.1 Basic medicine;1.4 Chemical sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;Immunology;Pharmacology;Pharmacology (medical) |
Issue Date: | Apr-2022 |
Citation: | Skesters , A , Kustovs , D , Lece , A , Moreino , E , Petrosina , E & Rainsford , K D 2022 , ' Selenium, selenoprotein P, and oxidative stress levels in SARS-CoV-2 patients during illness and recovery ' , Inflammopharmacology , vol. 30 , no. 2 , pp. 499-503 . https://doi.org/10.1007/s10787-022-00925-z |
Abstract: | Background: This study aimed to assess tendency of oxidative stress in COVID-19 patients depending on severity. Methods: The study was conducted with 80 post-COVID-19 disease patients and 40 acutely ill patients. Content of selenium in blood plasma was detected by a fluorimetric method with di-amino-naphthalene using acidic hydrolysis. Selenoprotein P, malondialdehyde and 4-hydroxynonenal and their metabolite adducts were evaluated by spectrophotometric methods using commercial assay kits. Results: Obtained results showed that selenium content in blood for post-COVID-19 disease patients was of a similar lower norm for Latvian inhabitants. Selenium and seleno-protein P contents for acute patients were significantly decreased compared with post-COVID-19 disease patients. Conclusion: In conclusion, COVID-19 involves induction of antioxidant systems—in case of severe disease, patients have significantly low concentration of selenium, seleno-protein P and higher level of oxidative stress, which, in turn, confirms the more intense formation of free radicals in the body. |
Description: | Publisher Copyright: © 2022, The Author(s). |
DOI: | 10.1007/s10787-022-00925-z |
ISSN: | 0925-4692 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Skesters2022_Article_SeleniumSelenoproteinPAndOxida.pdf | 503.91 kB | Adobe PDF | View/Open |
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