Title: | Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system |
Authors: | Hellsten, Sofie Hagglund, Maria Bagchi, Sonchita Ljungdahl, Anna Nilsson, Victor Winnergren, Sonja Stephansson, Olga Svirskis, Šimons Rumaks, Juris Klusa, Vija Schioth, Helgi Fredriksson, Robert |
Keywords: | 3.2 Clinical medicine;1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions) |
Issue Date: | 14-May-2013 |
Citation: | Hellsten , S , Hagglund , M , Bagchi , S , Ljungdahl , A , Nilsson , V , Winnergren , S , Stephansson , O , Svirskis , Š , Rumaks , J , Klusa , V , Schioth , H & Fredriksson , R 2013 , ' Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system ' , BMC Neuroscience , vol. 54 , no. 14 , pp. 1-18 . |
Abstract: | Background The vesicular B0AT3 transporter (SLC6A17), one of the members of the SLC6 family, is a transporter for neutral amino acids and is exclusively expressed in brain. Here we provide a comprehensive expression profile of B0AT3 in mouse brain using in situ hybridization and immunohistochemistry. Results We confirmed previous expression data from rat brain and used a novel custom made antibody to obtain detailed co-labelling with several cell type specific markers. B0AT3 was highly expressed in both inhibitory and excitatory neurons. The B0AT3 expression was highly overlapping with those of vesicular glutamate transporter 2 (VGLUT2) and vesicular glutamate transporter 1 (VGLUT1). We also show here that Slc6a17mRNA is up-regulated in animals subjected to short term food deprivation as well as animals treated with the serotonin reuptake inhibitor fluoxetine and the dopamine/noradrenaline reuptake inhibitor bupropion. Conclusions This suggests that the B0AT3 transporter have a role in regulation of monoaminergic as well as glutamatergic synapses. |
ISSN: | 1471-2202 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Characterization_of_the_transporterB0AT3_Slc6a17_in_the_rodent_central_nervous_system.pdf | 3.78 MB | Adobe PDF | View/Open |
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