Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Hellsten, Sofie | - |
dc.contributor.author | Hagglund, Maria | - |
dc.contributor.author | Bagchi, Sonchita | - |
dc.contributor.author | Ljungdahl, Anna | - |
dc.contributor.author | Nilsson, Victor | - |
dc.contributor.author | Winnergren, Sonja | - |
dc.contributor.author | Stephansson, Olga | - |
dc.contributor.author | Svirskis, Šimons | - |
dc.contributor.author | Rumaks, Juris | - |
dc.contributor.author | Klusa, Vija | - |
dc.contributor.author | Schioth, Helgi | - |
dc.contributor.author | Fredriksson, Robert | - |
dc.date.accessioned | 2022-02-03T11:00:02Z | - |
dc.date.available | 2022-02-03T11:00:02Z | - |
dc.date.issued | 2013-05-14 | - |
dc.identifier.citation | Hellsten , S , Hagglund , M , Bagchi , S , Ljungdahl , A , Nilsson , V , Winnergren , S , Stephansson , O , Svirskis , Š , Rumaks , J , Klusa , V , Schioth , H & Fredriksson , R 2013 , ' Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system ' , BMC Neuroscience , vol. 54 , no. 14 , pp. 1-18 . | - |
dc.identifier.issn | 1471-2202 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/7443 | - |
dc.description.abstract | Background The vesicular B0AT3 transporter (SLC6A17), one of the members of the SLC6 family, is a transporter for neutral amino acids and is exclusively expressed in brain. Here we provide a comprehensive expression profile of B0AT3 in mouse brain using in situ hybridization and immunohistochemistry. Results We confirmed previous expression data from rat brain and used a novel custom made antibody to obtain detailed co-labelling with several cell type specific markers. B0AT3 was highly expressed in both inhibitory and excitatory neurons. The B0AT3 expression was highly overlapping with those of vesicular glutamate transporter 2 (VGLUT2) and vesicular glutamate transporter 1 (VGLUT1). We also show here that Slc6a17mRNA is up-regulated in animals subjected to short term food deprivation as well as animals treated with the serotonin reuptake inhibitor fluoxetine and the dopamine/noradrenaline reuptake inhibitor bupropion. Conclusions This suggests that the B0AT3 transporter have a role in regulation of monoaminergic as well as glutamatergic synapses. | en |
dc.format.extent | 18 | - |
dc.format.extent | 3867452 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | BMC Neuroscience | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions) | - |
dc.title | Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Characterization_of_the_transporterB0AT3_Slc6a17_in_the_rodent_central_nervous_system.pdf | 3.78 MB | Adobe PDF | View/Open |
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