Please use this identifier to cite or link to this item:
10.3390/ijms22042129
Title: | Gastric carcinomas with stromal b7-h3 expression have lower intratumoural cd8+ t cell density |
Authors: | Ulase, Dita Behrens, Hans Michael Krüger, Sandra Zeissig, Sebastian Röcken, Christoph Department of Pathology |
Keywords: | B7-H3;CD8-Positive T-Lymphocytes;Gastric cancer;Immune checkpoint;Immune evasion;Immunohistochemistry;Tumour escape;Tumour microenvironment;3.1 Basic medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Catalysis;Molecular Biology;Spectroscopy;Computer Science Applications;Physical and Theoretical Chemistry;Organic Chemistry;Inorganic Chemistry;SDG 3 - Good Health and Well-being |
Issue Date: | 2-Feb-2021 |
Citation: | Ulase , D , Behrens , H M , Krüger , S , Zeissig , S & Röcken , C 2021 , ' Gastric carcinomas with stromal b7-h3 expression have lower intratumoural cd8+ t cell density ' , International Journal of Molecular Sciences , vol. 22 , no. 4 , 2129 , pp. 1-8 . https://doi.org/10.3390/ijms22042129 |
Abstract: | CD8+ T cells are the main effector cells of anti-cancer immune response that can be regulated by various costimulatory and coinhibitory molecules, including members of the B7 family. B7 homolog 3 (B7-H3) appears as a promising marker for immunotherapy; however, its significance in gastric cancer (GC) is unclear yet. We evaluated the spatial distribution of CD8+ T cells in relation to the expression of B7-H3 by double immunohistochemical staining. The level of B7-H3 intensity was scored manually (0-3) and dichotomized into B7-H3-low and B7-H3-high groups. The distribution and density of CD8+ T cells was analysed using whole slide digital imaging. B7-H3 was expressed mainly in the stromal compartment of GC (n = 73, 76% of all cases). Tumours with high expression of B7-H3 showed larger spatial differences of CD8+ T cells (86.4/mm2 in tumour centre vs. 414.9/mm2 in invasive front) when compared to B7-H3-low group (157.7/mm2 vs. 218.7/mm2, respectively) (p < 0.001). This study provides insight into the expression pattern of B7-H3 in GC of Western origin. In GCs with higher level of B7-H3 expression, CD8+ T cells were spatially suppressed in the tumour centre suggesting that B7-H3 might be involved in tumour escape mechanisms from the immune response. |
Description: | Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
DOI: | 10.3390/ijms22042129 |
ISSN: | 1661-6596 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Gastric_Carcinomas_with_Stromal_B7_H3_Expression_Have_Lower.pdf | 1.59 MB | Adobe PDF | View/Open |
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