Please use this identifier to cite or link to this item:
10.3390/ijms22042129
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DC Field | Value | Language |
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dc.contributor.author | Ulase, Dita | - |
dc.contributor.author | Behrens, Hans Michael | - |
dc.contributor.author | Krüger, Sandra | - |
dc.contributor.author | Zeissig, Sebastian | - |
dc.contributor.author | Röcken, Christoph | - |
dc.date.accessioned | 2022-01-18T08:05:01Z | - |
dc.date.available | 2022-01-18T08:05:01Z | - |
dc.date.issued | 2021-02-02 | - |
dc.identifier.citation | Ulase , D , Behrens , H M , Krüger , S , Zeissig , S & Röcken , C 2021 , ' Gastric carcinomas with stromal b7-h3 expression have lower intratumoural cd8+ t cell density ' , International Journal of Molecular Sciences , vol. 22 , no. 4 , 2129 , pp. 1-8 . https://doi.org/10.3390/ijms22042129 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/7212 | - |
dc.description | Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.description.abstract | CD8+ T cells are the main effector cells of anti-cancer immune response that can be regulated by various costimulatory and coinhibitory molecules, including members of the B7 family. B7 homolog 3 (B7-H3) appears as a promising marker for immunotherapy; however, its significance in gastric cancer (GC) is unclear yet. We evaluated the spatial distribution of CD8+ T cells in relation to the expression of B7-H3 by double immunohistochemical staining. The level of B7-H3 intensity was scored manually (0-3) and dichotomized into B7-H3-low and B7-H3-high groups. The distribution and density of CD8+ T cells was analysed using whole slide digital imaging. B7-H3 was expressed mainly in the stromal compartment of GC (n = 73, 76% of all cases). Tumours with high expression of B7-H3 showed larger spatial differences of CD8+ T cells (86.4/mm2 in tumour centre vs. 414.9/mm2 in invasive front) when compared to B7-H3-low group (157.7/mm2 vs. 218.7/mm2, respectively) (p < 0.001). This study provides insight into the expression pattern of B7-H3 in GC of Western origin. In GCs with higher level of B7-H3 expression, CD8+ T cells were spatially suppressed in the tumour centre suggesting that B7-H3 might be involved in tumour escape mechanisms from the immune response. | en |
dc.format.extent | 8 | - |
dc.format.extent | 1623403 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | International Journal of Molecular Sciences | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | B7-H3 | - |
dc.subject | CD8-Positive T-Lymphocytes | - |
dc.subject | Gastric cancer | - |
dc.subject | Immune checkpoint | - |
dc.subject | Immune evasion | - |
dc.subject | Immunohistochemistry | - |
dc.subject | Tumour escape | - |
dc.subject | Tumour microenvironment | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Catalysis | - |
dc.subject | Molecular Biology | - |
dc.subject | Spectroscopy | - |
dc.subject | Computer Science Applications | - |
dc.subject | Physical and Theoretical Chemistry | - |
dc.subject | Organic Chemistry | - |
dc.subject | Inorganic Chemistry | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Gastric carcinomas with stromal b7-h3 expression have lower intratumoural cd8+ t cell density | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/ijms22042129 | - |
dc.contributor.institution | Department of Pathology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85100917909&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Gastric_Carcinomas_with_Stromal_B7_H3_Expression_Have_Lower.pdf | 1.59 MB | Adobe PDF | View/Open |
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