Please use this identifier to cite or link to this item:
10.1016/j.jtho.2015.12.096
| Title: | Squamous cell carcinoma "transformation" concurrent with secondary T790M mutation in resistant EGFR-mutated adenocarcinomas |
| Authors: | Jukna, Agita Montanari, Gloria Mengoli, Maria Cecilia Cavazza, Alberto Covi, Marisa Barbieri, Fausto Bertolini, Federica Rossi, Giulio Department of Pathology |
| Keywords: | Adenocarcinoma;EGFR;Lung;Squamous cell carcinoma;T790M;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Oncology;Pulmonary and Respiratory Medicine |
| Issue Date: | 2016 |
| Citation: | Jukna , A , Montanari , G , Mengoli , M C , Cavazza , A , Covi , M , Barbieri , F , Bertolini , F & Rossi , G 2016 , ' Squamous cell carcinoma "transformation" concurrent with secondary T790M mutation in resistant EGFR-mutated adenocarcinomas ' , Journal of Thoracic Oncology , vol. 11 , no. 4 , pp. e49-e51 . https://doi.org/10.1016/j.jtho.2015.12.096 |
| Abstract: | The authors report two cases of epidermal growth factor receptor gene (EGFR)-mutant stage IV lung adenocarcinomas developing immunohistochemically proven squamous cell carcinoma (SCC) "transformation" concurrently with T790M EGFR mutation, leading to acquired resistance to EGFR inhibitors. Moreover, the histologic change of EGFR-mutant lung adenocarcinoma into SCC has been recently reported in literature. The histological transformation to SCC appears as a novel mechanism of acquired EGFR TKI resistance in EGFR-mutated adenocarcinomas and it may be challenging for treatment. |
| Description: | Publisher Copyright: © 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. |
| DOI: | 10.1016/j.jtho.2015.12.096 |
| ISSN: | 1556-0864 |
| Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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| File | Size | Format | |
|---|---|---|---|
| Squamous_Cell_Carcinoma_Transformation.pdf | 679.05 kB | Adobe PDF | View/Open |
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