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  2. Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure
  3. Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure
Please use this identifier to cite or link to this item: 10.1016/j.jtho.2015.12.096
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dc.contributor.authorJukna, Agita-
dc.contributor.authorMontanari, Gloria-
dc.contributor.authorMengoli, Maria Cecilia-
dc.contributor.authorCavazza, Alberto-
dc.contributor.authorCovi, Marisa-
dc.contributor.authorBarbieri, Fausto-
dc.contributor.authorBertolini, Federica-
dc.contributor.authorRossi, Giulio-
dc.date.accessioned2021-10-04T07:00:01Z-
dc.date.available2021-10-04T07:00:01Z-
dc.date.issued2016-
dc.identifier.citationJukna , A , Montanari , G , Mengoli , M C , Cavazza , A , Covi , M , Barbieri , F , Bertolini , F & Rossi , G 2016 , ' Squamous cell carcinoma "transformation" concurrent with secondary T790M mutation in resistant EGFR-mutated adenocarcinomas ' , Journal of Thoracic Oncology , vol. 11 , no. 4 , pp. e49-e51 . https://doi.org/10.1016/j.jtho.2015.12.096-
dc.identifier.issn1556-0864-
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6490-
dc.descriptionPublisher Copyright: © 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc.-
dc.description.abstractThe authors report two cases of epidermal growth factor receptor gene (EGFR)-mutant stage IV lung adenocarcinomas developing immunohistochemically proven squamous cell carcinoma (SCC) "transformation" concurrently with T790M EGFR mutation, leading to acquired resistance to EGFR inhibitors. Moreover, the histologic change of EGFR-mutant lung adenocarcinoma into SCC has been recently reported in literature. The histological transformation to SCC appears as a novel mechanism of acquired EGFR TKI resistance in EGFR-mutated adenocarcinomas and it may be challenging for treatment.en
dc.format.extent3-
dc.format.extent695344-
dc.language.isoeng-
dc.relation.ispartofJournal of Thoracic Oncology-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.subjectAdenocarcinoma-
dc.subjectEGFR-
dc.subjectLung-
dc.subjectSquamous cell carcinoma-
dc.subjectT790M-
dc.subject3.2 Clinical medicine-
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database-
dc.subjectOncology-
dc.subjectPulmonary and Respiratory Medicine-
dc.titleSquamous cell carcinoma "transformation" concurrent with secondary T790M mutation in resistant EGFR-mutated adenocarcinomasen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article-
dc.identifier.doi10.1016/j.jtho.2015.12.096-
dc.contributor.institutionDepartment of Pathology-
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84962815723&partnerID=8YFLogxK-
dc.description.statusPeer reviewed-
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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