Please use this identifier to cite or link to this item:
10.1038/sj.ijo.0803505
Title: | The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population |
Authors: | Felder, T.K. Oberkofler, H. Weitgasser, R. Mackevics, V. Krempler, F. Paulweber, B. Patsch, W. Department of Internal Diseases |
Keywords: | Adiponectin;Single nucleotide polymorphism;SREBP-1c;Type 2 diabetes;3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Medicine (miscellaneous);Endocrinology, Diabetes and Metabolism;Nutrition and Dietetics;SDG 3 - Good Health and Well-being |
Issue Date: | 10-Jul-2007 |
Citation: | Felder , T K , Oberkofler , H , Weitgasser , R , Mackevics , V , Krempler , F , Paulweber , B & Patsch , W 2007 , ' The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population ' , International Journal of Obesity , vol. 31 , no. 7 , pp. 1099-1103 . https://doi.org/10.1038/sj.ijo.0803505 |
Abstract: | Context: The sterol regulatory element-binding protein-1c (SREBP-1c) is a transcription factor involved in the regulation of lipid and glucose metabolism and has been implicated in the pathophysiology of type 2 diabetes mellitus (T2DM). Objective: We aimed to confirm associations of the SREBF-1 gene with T2DM in an Austrian population and to study possible associations with diabetes-related quantitative traits. Design, settings and participants: We genotyped a diabetic cohort (n=446) along with a control group (n=1524) for a common C/G variation that is located in exon 18c (rs2297508) and has been associated with obesity and T2DM in French populations. Main outcome measures: Body mass index (BMI), indices of insulin sensitivity and β-cell function, plasma adiponectin, T2DM and single-nucleotide polymorphism rs2297508. Results: Genotype distributions associated with rs2297508 differed by T2DM status (P=0.0045), but not by BMI. The variant G allele was associated with a modest, but significant, increase in the prevalence of T2DM after adjustment for age, sex and BMI (G/G: odds ratios (OR) (95% confidence intervals)=1.45 (0.99-2.11) and G/C: OR=1.37 (1.04-1.81)). In a cross-sectional population of non-diabetic subjects, associations of rs2297508 genotypes with plasma adiponectin levels adjusted for age, sex and BMI (P=0.0017) were observed in that the risk G/G genotype displayed the lowest adiponectin levels. Conclusions: We observed associations of rs2297508 with T2DM prevalence and plasma adiponectin. SREBP-1c has been implicated in the regulation of adiponectin gene expression. Our results therefore raise the possibility that sequence variations at the SREBF-1 gene locus might contribute to T2DM risk, at least in part, by altering circulating adiponectin levels. |
Description: | Funding Information: This study was supported by grants from the Oesterrei-chische Nationalbank (Project No. 10678 and 10932), the Medizinische Forschungsgesellschaft Salzburg and a grant from the Land Salzburg. Copyright: Copyright 2011 Elsevier B.V., All rights reserved. |
DOI: | 10.1038/sj.ijo.0803505 |
ISSN: | 0307-0565 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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