Please use this identifier to cite or link to this item:
10.1038/sj.ijo.0803505
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Felder, T.K. | - |
dc.contributor.author | Oberkofler, H. | - |
dc.contributor.author | Weitgasser, R. | - |
dc.contributor.author | Mackevics, V. | - |
dc.contributor.author | Krempler, F. | - |
dc.contributor.author | Paulweber, B. | - |
dc.contributor.author | Patsch, W. | - |
dc.date.accessioned | 2021-09-17T08:05:01Z | - |
dc.date.available | 2021-09-17T08:05:01Z | - |
dc.date.issued | 2007-07-10 | - |
dc.identifier.citation | Felder , T K , Oberkofler , H , Weitgasser , R , Mackevics , V , Krempler , F , Paulweber , B & Patsch , W 2007 , ' The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population ' , International Journal of Obesity , vol. 31 , no. 7 , pp. 1099-1103 . https://doi.org/10.1038/sj.ijo.0803505 | - |
dc.identifier.issn | 0307-0565 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/6381 | - |
dc.description | Funding Information: This study was supported by grants from the Oesterrei-chische Nationalbank (Project No. 10678 and 10932), the Medizinische Forschungsgesellschaft Salzburg and a grant from the Land Salzburg. Copyright: Copyright 2011 Elsevier B.V., All rights reserved. | - |
dc.description.abstract | Context: The sterol regulatory element-binding protein-1c (SREBP-1c) is a transcription factor involved in the regulation of lipid and glucose metabolism and has been implicated in the pathophysiology of type 2 diabetes mellitus (T2DM). Objective: We aimed to confirm associations of the SREBF-1 gene with T2DM in an Austrian population and to study possible associations with diabetes-related quantitative traits. Design, settings and participants: We genotyped a diabetic cohort (n=446) along with a control group (n=1524) for a common C/G variation that is located in exon 18c (rs2297508) and has been associated with obesity and T2DM in French populations. Main outcome measures: Body mass index (BMI), indices of insulin sensitivity and β-cell function, plasma adiponectin, T2DM and single-nucleotide polymorphism rs2297508. Results: Genotype distributions associated with rs2297508 differed by T2DM status (P=0.0045), but not by BMI. The variant G allele was associated with a modest, but significant, increase in the prevalence of T2DM after adjustment for age, sex and BMI (G/G: odds ratios (OR) (95% confidence intervals)=1.45 (0.99-2.11) and G/C: OR=1.37 (1.04-1.81)). In a cross-sectional population of non-diabetic subjects, associations of rs2297508 genotypes with plasma adiponectin levels adjusted for age, sex and BMI (P=0.0017) were observed in that the risk G/G genotype displayed the lowest adiponectin levels. Conclusions: We observed associations of rs2297508 with T2DM prevalence and plasma adiponectin. SREBP-1c has been implicated in the regulation of adiponectin gene expression. Our results therefore raise the possibility that sequence variations at the SREBF-1 gene locus might contribute to T2DM risk, at least in part, by altering circulating adiponectin levels. | en |
dc.format.extent | 5 | - |
dc.format.extent | 103648 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | International Journal of Obesity | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Adiponectin | - |
dc.subject | Single nucleotide polymorphism | - |
dc.subject | SREBP-1c | - |
dc.subject | Type 2 diabetes | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Medicine (miscellaneous) | - |
dc.subject | Endocrinology, Diabetes and Metabolism | - |
dc.subject | Nutrition and Dietetics | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1038/sj.ijo.0803505 | - |
dc.contributor.institution | Department of Internal Diseases | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=34250888726&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
---|---|---|---|
The_SREBF_1_locus_is_associated_with_type_2_diabetes.pdf | 101.22 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.