Please use this identifier to cite or link to this item: 10.1177/0009922810394838
Title: Treatment of streptococcal pharyngitis with once-daily amoxicillin versus intramuscular benzathine penicillin g in low-resource settings : A randomized controlled trial
Authors: Rimoin, Anne W.
Hoff, Nicole A.
Fischer Walker, Christa L.
Hamza, Hala S.
Vince, Adriana
Rahman, Naglaa Abdel
Andrasevic, Sasa
Emam, Soha
Vukelic, Dubravka
Elminawi, Nevine
Ghafar, Hadeer Abdel
Da Cunha, Antonia L.A.
Qazi, Shamim
Gardovska, Dace
Steinhoff, Mark C.
Rīga Stradiņš University
Keywords: amoxicillin;intramuscular benzathine penicillin G;randomized clinical trial;streptococcal pharyngitis;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Pediatrics, Perinatology, and Child Health
Issue Date: Jun-2011
Citation: Rimoin , A W , Hoff , N A , Fischer Walker , C L , Hamza , H S , Vince , A , Rahman , N A , Andrasevic , S , Emam , S , Vukelic , D , Elminawi , N , Ghafar , H A , Da Cunha , A L A , Qazi , S , Gardovska , D & Steinhoff , M C 2011 , ' Treatment of streptococcal pharyngitis with once-daily amoxicillin versus intramuscular benzathine penicillin g in low-resource settings : A randomized controlled trial ' , Clinical Pediatrics , vol. 50 , no. 6 , pp. 535-542 . https://doi.org/10.1177/0009922810394838
Abstract: Background: Primary prevention of acute rheumatic fever is achieved by proper antibiotic treatment of group A β -hemolytic streptococcal (GAS) pharyngitis. Methods: To assess noninferiority of oral amoxicillin to intramuscular benzathine penicillin G (IM BPG). Children (2 to 12 years) meeting enrollment criteria were randomized 1:1 to receive antibiotic treatment in 2 urban outpatient clinics in Egypt and Croatia. Results: A total of 558 children (Croatia = 166, Egypt = 392) were randomized, with 368 evaluable in an intention-to-treat (ITT) analysis, and 272 evaluable in the per protocol (PP) analysis. In Croatia, ITT and PP treatment success rates were comparable for IM BPG and amoxicillin (2.5% difference vs 1.1% difference, respectively). In Egypt, amoxicillin was not comparable with IM BPG in ITT analysis (15.1% difference), but was comparable in PP analysis (-9.3% difference). Conclusion: If compliance is a major issue, a single dose of IM BPG may be preferable for treatment of GAS pharyngitis.
DOI: 10.1177/0009922810394838
ISSN: 0009-9228
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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