Please use this identifier to cite or link to this item:
10.1186/s13053-015-0028-z
Title: | High expression of miR-214 is associated with a worse disease-specific survival of the triple-negative breast cancer patients |
Authors: | Kalniete, Dagnija Nakazawa-Miklaševiča, Miki Štrumfa, Ilze Abolinš, Arnis Irmejs, Arvids Gardovskis, Janis Miklaševičs, Edvins RSU Institute of Oncology Rīga Stradiņš University |
Keywords: | Hereditary and sporadic breast cancers;MiRNA expressionm;Triple-negative subtype;3.2 Clinical medicine;3.1 Basic medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Oncology;Genetics(clinical);SDG 3 - Good Health and Well-being |
Issue Date: | 8-Feb-2015 |
Citation: | Kalniete , D , Nakazawa-Miklaševiča , M , Štrumfa , I , Abolinš , A , Irmejs , A , Gardovskis , J & Miklaševičs , E 2015 , ' High expression of miR-214 is associated with a worse disease-specific survival of the triple-negative breast cancer patients ' , Hereditary cancer in clinical practice , vol. 13 , no. 1 , 7 . https://doi.org/10.1186/s13053-015-0028-z |
Abstract: | Background: Hereditary triple-negative breast cancer patients have better recurrence-free survival than triple-negative sporadic ones. High expression of some of the miRNAs is related to worse overall and disease-free survival of triple-negative breast cancer patients. The attempt to associate expression level of some miRNA in triple-negative hereditary and sporadic breast cancers to disease specific survival was performed in this study. Material and methods: Study group was made of 18 triple-negative breast cancer patients harboring the BRCA1 gene mutations and 32 triple-negative sporadic breast cancer patients. Quantitative amount of mir-10b, mir-21, mir-29a, mir-31, and mir-214 by real-time PCR was assessed. The disease-specific survival in relation of high and low levels of some of the miRNAs was analyzed using Log-rank (Mantel-Cox) test. Results: MiR-214 showed significantly higher expression level in sporadic tissues than in hereditary ones (p=0.0005). Triple-negative breast cancer patients with high level of miR-214 showed significantly worse disease-specific survival than patients with low level (p=0.0314). Conclusions: Our finding suggests that miR-214 possibly could be used as a potential prognostic biomarker for triple-negative breast cancer patients. |
Description: | Publisher Copyright: © Kalniete et al.; licensee BioMed Central. |
DOI: | 10.1186/s13053-015-0028-z |
ISSN: | 1731-2302 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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