Please use this identifier to cite or link to this item:
10.1186/s13053-015-0028-z
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kalniete, Dagnija | - |
dc.contributor.author | Nakazawa-Miklaševiča, Miki | - |
dc.contributor.author | Štrumfa, Ilze | - |
dc.contributor.author | Abolinš, Arnis | - |
dc.contributor.author | Irmejs, Arvids | - |
dc.contributor.author | Gardovskis, Janis | - |
dc.contributor.author | Miklaševičs, Edvins | - |
dc.date.accessioned | 2021-07-02T12:00:01Z | - |
dc.date.available | 2021-07-02T12:00:01Z | - |
dc.date.issued | 2015-02-08 | - |
dc.identifier.citation | Kalniete , D , Nakazawa-Miklaševiča , M , Štrumfa , I , Abolinš , A , Irmejs , A , Gardovskis , J & Miklaševičs , E 2015 , ' High expression of miR-214 is associated with a worse disease-specific survival of the triple-negative breast cancer patients ' , Hereditary cancer in clinical practice , vol. 13 , no. 1 , 7 . https://doi.org/10.1186/s13053-015-0028-z | - |
dc.identifier.issn | 1731-2302 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/5823 | - |
dc.description | Publisher Copyright: © Kalniete et al.; licensee BioMed Central. | - |
dc.description.abstract | Background: Hereditary triple-negative breast cancer patients have better recurrence-free survival than triple-negative sporadic ones. High expression of some of the miRNAs is related to worse overall and disease-free survival of triple-negative breast cancer patients. The attempt to associate expression level of some miRNA in triple-negative hereditary and sporadic breast cancers to disease specific survival was performed in this study. Material and methods: Study group was made of 18 triple-negative breast cancer patients harboring the BRCA1 gene mutations and 32 triple-negative sporadic breast cancer patients. Quantitative amount of mir-10b, mir-21, mir-29a, mir-31, and mir-214 by real-time PCR was assessed. The disease-specific survival in relation of high and low levels of some of the miRNAs was analyzed using Log-rank (Mantel-Cox) test. Results: MiR-214 showed significantly higher expression level in sporadic tissues than in hereditary ones (p=0.0005). Triple-negative breast cancer patients with high level of miR-214 showed significantly worse disease-specific survival than patients with low level (p=0.0314). Conclusions: Our finding suggests that miR-214 possibly could be used as a potential prognostic biomarker for triple-negative breast cancer patients. | en |
dc.format.extent | 516654 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Hereditary cancer in clinical practice | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Hereditary and sporadic breast cancers | - |
dc.subject | MiRNA expressionm | - |
dc.subject | Triple-negative subtype | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Oncology | - |
dc.subject | Genetics(clinical) | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | High expression of miR-214 is associated with a worse disease-specific survival of the triple-negative breast cancer patients | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1186/s13053-015-0028-z | - |
dc.contributor.institution | RSU Institute of Oncology | - |
dc.contributor.institution | Rīga Stradiņš University | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84924259580&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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High_expression_of_miR_214.pdf | 504.54 kB | Adobe PDF | View/Open |
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