Please use this identifier to cite or link to this item:
10.1111/bjh.15587
Title: | Complex and monosomal karyotype are distinct cytogenetic entities with an adverse prognostic impact in paediatric acute myeloid leukaemia. A NOPHO-DBH-AML study |
Authors: | Bager, Ninna Juul-Dam, Kristian L. Sandahl, Julie D. Abrahamsson, Jonas Beverloo, Berna de Bont, Eveline S.J.M. Ha, Shau Yin Jahnukainen, Kirsi Jónsson, Ólafur G. Kaspers, Gertjan L. Kovalova, Zhanna Lausen, Birgitte De Moerloose, Barbara Noren-Nyström, Ulrika Palle, Josefine Saks, Kadri Zeller, Bernward Kjeldsen, Eigil Hasle, Henrik |
Keywords: | Acute myeloid leukaemia;complex karyotype;monosomal karyotype;paediatrics;refractory disease;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Hematology |
Issue Date: | Nov-2018 |
Citation: | Bager , N , Juul-Dam , K L , Sandahl , J D , Abrahamsson , J , Beverloo , B , de Bont , E S J M , Ha , S Y , Jahnukainen , K , Jónsson , Ó G , Kaspers , G L , Kovalova , Z , Lausen , B , De Moerloose , B , Noren-Nyström , U , Palle , J , Saks , K , Zeller , B , Kjeldsen , E & Hasle , H 2018 , ' Complex and monosomal karyotype are distinct cytogenetic entities with an adverse prognostic impact in paediatric acute myeloid leukaemia. A NOPHO-DBH-AML study ' , British Journal of Haematology , vol. 183 , no. 4 , pp. 618-628 . https://doi.org/10.1111/bjh.15587 |
Abstract: | Data on occurrence, genetic characteristics and prognostic impact of complex and monosomal karyotype (CK/MK) in children with acute myeloid leukaemia (AML) are scarce. We studied CK and MK in a large unselected cohort of childhood AML patients diagnosed and treated according to Nordic Society for Paediatric Haematology and Oncology (NOPHO)-AML protocols 1993–2015. In total, 800 patients with de novo AML were included. CK was found in 122 (15%) and MK in 41 (5%) patients. CK and MK patients were young (median age 2·1 and 3·3 years, respectively) and frequently had FAB M7 morphology (24% and 22%, respectively). Refractory disease was more common in MK patients (15% vs. 4%) and stem cell transplantation in first complete remission was more frequent (32% vs. 19%) compared with non-CK/non-MK patients. CK showed no association with refractory disease but was an independent predictor of an inferior event-free survival (EFS; hazard ratio [HR] 1·43, P = 0·03) and overall survival (OS; HR 1·48, P = 0·01). MK was associated with a poor EFS (HR 1·57, P = 0·03) but did not show an inferior OS compared to non-MK patients (HR 1·14, P = 0·62). In a large paediatric cohort, we characterized AML with non-recurrent abnormal karyotype and unravelled the adverse impact of CK and MK on prognosis. |
Description: | Funding Information: The study was supported by the Danish Childhood Cancer Foundation. Furthermore, all the work done by the cytogenetic groups in NOPHO is acknowledged. Publisher Copyright: © 2018 British Society for Haematology and John Wiley & Sons Ltd |
DOI: | 10.1111/bjh.15587 |
ISSN: | 0007-1048 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
---|---|---|---|
Complex_and_monosomal_karyotyp.pdf | 299.78 kB | Adobe PDF | View/Open![]() |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.