Please use this identifier to cite or link to this item:
10.1111/bjh.15587
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DC Field | Value | Language |
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dc.contributor.author | Bager, Ninna | - |
dc.contributor.author | Juul-Dam, Kristian L. | - |
dc.contributor.author | Sandahl, Julie D. | - |
dc.contributor.author | Abrahamsson, Jonas | - |
dc.contributor.author | Beverloo, Berna | - |
dc.contributor.author | de Bont, Eveline S.J.M. | - |
dc.contributor.author | Ha, Shau Yin | - |
dc.contributor.author | Jahnukainen, Kirsi | - |
dc.contributor.author | Jónsson, Ólafur G. | - |
dc.contributor.author | Kaspers, Gertjan L. | - |
dc.contributor.author | Kovalova, Zhanna | - |
dc.contributor.author | Lausen, Birgitte | - |
dc.contributor.author | De Moerloose, Barbara | - |
dc.contributor.author | Noren-Nyström, Ulrika | - |
dc.contributor.author | Palle, Josefine | - |
dc.contributor.author | Saks, Kadri | - |
dc.contributor.author | Zeller, Bernward | - |
dc.contributor.author | Kjeldsen, Eigil | - |
dc.contributor.author | Hasle, Henrik | - |
dc.date.accessioned | 2021-06-03T15:30:01Z | - |
dc.date.available | 2021-06-03T15:30:01Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.citation | Bager , N , Juul-Dam , K L , Sandahl , J D , Abrahamsson , J , Beverloo , B , de Bont , E S J M , Ha , S Y , Jahnukainen , K , Jónsson , Ó G , Kaspers , G L , Kovalova , Z , Lausen , B , De Moerloose , B , Noren-Nyström , U , Palle , J , Saks , K , Zeller , B , Kjeldsen , E & Hasle , H 2018 , ' Complex and monosomal karyotype are distinct cytogenetic entities with an adverse prognostic impact in paediatric acute myeloid leukaemia. A NOPHO-DBH-AML study ' , British Journal of Haematology , vol. 183 , no. 4 , pp. 618-628 . https://doi.org/10.1111/bjh.15587 | - |
dc.identifier.issn | 0007-1048 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/4695 | - |
dc.description | Funding Information: The study was supported by the Danish Childhood Cancer Foundation. Furthermore, all the work done by the cytogenetic groups in NOPHO is acknowledged. Publisher Copyright: © 2018 British Society for Haematology and John Wiley & Sons Ltd | - |
dc.description.abstract | Data on occurrence, genetic characteristics and prognostic impact of complex and monosomal karyotype (CK/MK) in children with acute myeloid leukaemia (AML) are scarce. We studied CK and MK in a large unselected cohort of childhood AML patients diagnosed and treated according to Nordic Society for Paediatric Haematology and Oncology (NOPHO)-AML protocols 1993–2015. In total, 800 patients with de novo AML were included. CK was found in 122 (15%) and MK in 41 (5%) patients. CK and MK patients were young (median age 2·1 and 3·3 years, respectively) and frequently had FAB M7 morphology (24% and 22%, respectively). Refractory disease was more common in MK patients (15% vs. 4%) and stem cell transplantation in first complete remission was more frequent (32% vs. 19%) compared with non-CK/non-MK patients. CK showed no association with refractory disease but was an independent predictor of an inferior event-free survival (EFS; hazard ratio [HR] 1·43, P = 0·03) and overall survival (OS; HR 1·48, P = 0·01). MK was associated with a poor EFS (HR 1·57, P = 0·03) but did not show an inferior OS compared to non-MK patients (HR 1·14, P = 0·62). In a large paediatric cohort, we characterized AML with non-recurrent abnormal karyotype and unravelled the adverse impact of CK and MK on prognosis. | en |
dc.format.extent | 11 | - |
dc.format.extent | 306976 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | British Journal of Haematology | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Acute myeloid leukaemia | - |
dc.subject | complex karyotype | - |
dc.subject | monosomal karyotype | - |
dc.subject | paediatrics | - |
dc.subject | refractory disease | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Hematology | - |
dc.title | Complex and monosomal karyotype are distinct cytogenetic entities with an adverse prognostic impact in paediatric acute myeloid leukaemia. A NOPHO-DBH-AML study | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1111/bjh.15587 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85056203633&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Complex_and_monosomal_karyotyp.pdf | 299.78 kB | Adobe PDF | View/Open![]() |
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