Please use this identifier to cite or link to this item:
10.1038/s41467-018-08054-4
| Title: | Shared heritability and functional enrichment across six solid cancers |
| Authors: | Jiang, Xia Finucane, Hilary K. Schumacher, Fredrick R. Schmit, Stephanie L. Tyrer, Jonathan P. Han, Younghun Michailidou, Kyriaki Lesseur, Corina Kuchenbaecker, Karoline B. Dennis, Joe Conti, David V. Casey, Graham Gaudet, Mia M. Huyghe, Jeroen R. Albanes, Demetrius Aldrich, Melinda C. Andrew, Angeline S. Andrulis, Irene L. Anton-Culver, Hoda Antoniou, Antonis C. Antonenkova, Natalia N. Arnold, Susanne M. Aronson, Kristan J. Arun, Banu K. Bandera, Elisa V. Barkardottir, Rosa B. Barnes, Daniel R. Batra, Jyotsna Beckmann, Matthias W. Benitez, Javier Benlloch, Sara Berchuck, Andrew Berndt, Sonja I. Bickeböller, Heike Bien, Stephanie A. Blomqvist, Carl Boccia, Stefania Bogdanova, Natalia V. Bojesen, Stig E. Bolla, Manjeet K. Brauch, Hiltrud Brenner, Hermann Brenton, James D. Brook, Mark N. Brunet, Joan Brunnström, Hans Buchanan, Daniel D. Burwinkel, Barbara Butzow, Ralf Cadoni, Gabriella Caldés, Trinidad Caligo, Maria A. Campbell, Ian Campbell, Peter T. Cancel-Tassin, Géraldine Cannon-Albright, Lisa Campa, Daniele Caporaso, Neil Carvalho, André L. Chan, Andrew T. Chang-Claude, Jenny Chanock, Stephen J. Chen, Chu Christiani, David C. Claes, Kathleen B.M. Claessens, Frank Clements, Judith Collée, J. Margriet Correa, Marcia Cruz Couch, Fergus J. Cox, Angela Cunningham, Julie M. Cybulski, Cezary Czene, Kamila Daly, Mary B. deFazio, Anna Devilee, Peter Diez, Orland Gago-Dominguez, Manuela Donovan, Jenny L. Dörk, Thilo Duell, Eric J. Dunning, Alison M. Dwek, Miriam Eccles, Diana M. Edlund, Christopher K. Edwards, Digna R.Velez Ellberg, Carolina Evans, D. Gareth Fasching, Peter A. Ferris, Robert L. Liloglou, Triantafillos Figueiredo, Jane C. Fletcher, Olivia Fortner, Renée T. Fostira, Florentia Franceschi, Silvia Friedman, Eitan Gallinger, Steven J. Ganz, Patricia A. Garber, Judy García-Sáenz, José A. Gayther, Simon A. Giles, Graham G. Godwin, Andrew K. Goldberg, Mark S. Goldgar, David E. Goode, Ellen L. Goodman, Marc T. Goodman, Gary Grankvist, Kjell Greene, Mark H. Gronberg, Henrik Gronwald, Jacek Guénel, Pascal Håkansson, Niclas Hall, Per Hamann, Ute Hamdy, Freddie C. Hamilton, Robert J. Hampe, Jochen Haugen, Aage Heitz, Florian Herrero, Rolando Hillemanns, Peter Hoffmeister, Michael Høgdall, Estrid Hong, Yun Chul Hopper, John L. Houlston, Richard Hulick, Peter J. Hunter, David J. Huntsman, David G. Idos, Gregory Imyanitov, Evgeny N. Ingles, Sue Ann Isaacs, Claudine Jakubowska, Anna James, Paul Jenkins, Mark A. Johansson, Mattias Johansson, Mikael John, Esther M. Joshi, Amit D. Kaneva, Radka Karlan, Beth Y. Kelemen, Linda E. Kühl, Tabea Khaw, Kay Tee Khusnutdinova, Elza Kibel, Adam S. Kiemeney, Lambertus A. Kim, Jeri Kjaer, Susanne K. Knight, Julia A. Kogevinas, Manolis Kote-Jarai, Zsofia Koutros, Stella Kristensen, Vessela N. Kupryjanczyk, Jolanta Lacko, Martin Lam, Stephan Lambrechts, Diether Landi, Maria Teresa Lazarus, Philip Le, Nhu D. Lee, Eunjung Lejbkowicz, Flavio Lenz, Heinz Josef Leslie, Goska Lessel, Davor Lester, Jenny Levine, Douglas A. Li, Li Li, Christopher I. Lindblom, Annika Lindor, Noralane M. Liu, Geoffrey Loupakis, Fotios Lubiński, Jan Maehle, Lovise Maier, Christiane Mannermaa, Arto Marchand, Loic Le Margolin, Sara May, Taymaa McGuffog, Lesley Meindl, Alfons Middha, Pooja Miller, Austin Milne, Roger L. MacInnis, Robert J. Modugno, Francesmary Montagna, Marco Moreno, Victor Moysich, Kirsten B. Mucci, Lorelei Muir, Kenneth Mulligan, Anna Marie Nathanson, Katherine L. Neal, David E. Ness, Andrew R. Neuhausen, Susan L. Nevanlinna, Heli Newcomb, Polly A. Newcomb, Lisa F. Nielsen, Finn Cilius Nikitina-Zake, Liene Nordestgaard, Børge G. Nussbaum, Robert L. Offit, Kenneth Olah, Edith Olama, Ali Amin Al Olopade, Olufunmilayo I. Olshan, Andrew F. Olsson, Håkan Osorio, Ana Pandha, Hardev Park, Jong Y. Pashayan, Nora Parsons, Michael T. Pejovic, Tanja Penney, Kathryn L. Peters, Wilbert H.M. Phelan, Catherine M. Phipps, Amanda I. Plaseska-Karanfilska, Dijana Pring, Miranda Prokofyeva, Darya Radice, Paolo Stefansson, Kari Ramus, Susan J. Raskin, Leon Rennert, Gad Rennert, Hedy S. van Rensburg, Elizabeth J. Riggan, Marjorie J. Risch, Harvey A. Risch, Angela Roobol, Monique J. Rosenstein, Barry S. Rossing, Mary Anne De Ruyck, Kim Saloustros, Emmanouil Sandler, Dale P. Sawyer, Elinor J. Schabath, Matthew B. Schleutker, Johanna Schmidt, Marjanka K. Setiawan, V. Wendy Shen, Hongbing Siegel, Erin M. Sieh, Weiva Singer, Christian F. Slattery, Martha L. Sorensen, Karina Dalsgaard Southey, Melissa C. Spurdle, Amanda B. Stanford, Janet L. Stevens, Victoria L. Stintzing, Sebastian Stone, Jennifer Sundfeldt, Karin Sutphen, Rebecca Swerdlow, Anthony J. Tajara, Eloiza H. Tangen, Catherine M. Tardon, Adonina Taylor, Jack A. Teare, M. Dawn Teixeira, Manuel R. Terry, Mary Beth Terry, Kathryn L. Thibodeau, Stephen N. Thomassen, Mads Bjørge, Line Tischkowitz, Marc Toland, Amanda E. Torres, Diana Townsend, Paul A. Travis, Ruth C. Tung, Nadine Tworoger, Shelley S. Ulrich, Cornelia M. Usmani, Nawaid Vachon, Celine M. Van Nieuwenhuysen, Els Vega, Ana Aguado-Barrera, Miguel Elías Wang, Qin Webb, Penelope M. Weinberg, Clarice R. Weinstein, Stephanie Weissler, Mark C. Weitzel, Jeffrey N. West, Catharine M.L. White, Emily Whittemore, Alice S. Wichmann, H. Erich Wiklund, Fredrik Winqvist, Robert Wolk, Alicja Woll, Penella Woods, Michael Wu, Anna H. Wu, Xifeng Yannoukakos, Drakoulis Zheng, Wei Zienolddiny, Shanbeh Ziogas, Argyrios Zorn, Kristin K. Lane, Jacqueline M. Saxena, Richa Thomas, Duncan Hung, Rayjean J. Diergaarde, Brenda McKay, James Peters, Ulrike Hsu, Li García-Closas, Montserrat Eeles, Rosalind A. Chenevix-Trench, Georgia Brennan, Paul J. Haiman, Christopher A. Simard, Jacques Easton, Douglas F. Gruber, Stephen B. Pharoah, Paul D.P. Price, Alkes L. Pasaniuc, Bogdan Amos, Christopher I. Kraft, Peter Lindström, Sara |
| Keywords: | 3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;SDG 3 - Good Health and Well-being |
| Issue Date: | 1-Dec-2019 |
| Citation: | Jiang , X , Finucane , H K , Schumacher , F R , Schmit , S L , Tyrer , J P , Han , Y , Michailidou , K , Lesseur , C , Kuchenbaecker , K B , Dennis , J , Conti , D V , Casey , G , Gaudet , M M , Huyghe , J R , Albanes , D , Aldrich , M C , Andrew , A S , Andrulis , I L , Anton-Culver , H , Antoniou , A C , Antonenkova , N N , Arnold , S M , Aronson , K J , Arun , B K , Bandera , E V , Barkardottir , R B , Barnes , D R , Batra , J , Beckmann , M W , Benitez , J , Benlloch , S , Berchuck , A , Berndt , S I , Bickeböller , H , Bien , S A , Blomqvist , C , Boccia , S , Bogdanova , N V , Bojesen , S E , Bolla , M K , Brauch , H , Brenner , H , Brenton , J D , Brook , M N , Brunet , J , Brunnström , H , Buchanan , D D , Burwinkel , B , Butzow , R , Cadoni , G , Caldés , T , Caligo , M A , Campbell , I , Campbell , P T , Cancel-Tassin , G , Cannon-Albright , L , Campa , D , Caporaso , N , Carvalho , A L , Chan , A T , Chang-Claude , J , Chanock , S J , Chen , C , Christiani , D C , Claes , K B M , Claessens , F , Clements , J , Collée , J M , Correa , M C , Couch , F J , Cox , A , Cunningham , J M , Cybulski , C , Czene , K , Daly , M B , deFazio , A , Devilee , P , Diez , O , Gago-Dominguez , M , Donovan , J L , Dörk , T , Duell , E J , Dunning , A M , Dwek , M , Eccles , D M , Edlund , C K , Edwards , D R V , Ellberg , C , Evans , D G , Fasching , P A , Ferris , R L , Liloglou , T , Figueiredo , J C , Fletcher , O , Fortner , R T , Fostira , F , Franceschi , S , Friedman , E , Gallinger , S J , Ganz , P A , Garber , J , García-Sáenz , J A , Gayther , S A , Giles , G G , Godwin , A K , Goldberg , M S , Goldgar , D E , Goode , E L , Goodman , M T , Goodman , G , Grankvist , K , Greene , M H , Gronberg , H , Gronwald , J , Guénel , P , Håkansson , N , Hall , P , Hamann , U , Hamdy , F C , Hamilton , R J , Hampe , J , Haugen , A , Heitz , F , Herrero , R , Hillemanns , P , Hoffmeister , M , Høgdall , E , Hong , Y C , Hopper , J L , Houlston , R , Hulick , P J , Hunter , D J , Huntsman , D G , Idos , G , Imyanitov , E N , Ingles , S A , Isaacs , C , Jakubowska , A , James , P , Jenkins , M A , Johansson , M , Johansson , M , John , E M , Joshi , A D , Kaneva , R , Karlan , B Y , Kelemen , L E , Kühl , T , Khaw , K T , Khusnutdinova , E , Kibel , A S , Kiemeney , L A , Kim , J , Kjaer , S K , Knight , J A , Kogevinas , M , Kote-Jarai , Z , Koutros , S , Kristensen , V N , Kupryjanczyk , J , Lacko , M , Lam , S , Lambrechts , D , Landi , M T , Lazarus , P , Le , N D , Lee , E , Lejbkowicz , F , Lenz , H J , Leslie , G , Lessel , D , Lester , J , Levine , D A , Li , L , Li , C I , Lindblom , A , Lindor , N M , Liu , G , Loupakis , F , Lubiński , J , Maehle , L , Maier , C , Mannermaa , A , Marchand , L L , Margolin , S , May , T , McGuffog , L , Meindl , A , Middha , P , Miller , A , Milne , R L , MacInnis , R J , Modugno , F , Montagna , M , Moreno , V , Moysich , K B , Mucci , L , Muir , K , Mulligan , A M , Nathanson , K L , Neal , D E , Ness , A R , Neuhausen , S L , Nevanlinna , H , Newcomb , P A , Newcomb , L F , Nielsen , F C , Nikitina-Zake , L , Nordestgaard , B G , Nussbaum , R L , Offit , K , Olah , E , Olama , A A A , Olopade , O I , Olshan , A F , Olsson , H , Osorio , A , Pandha , H , Park , J Y , Pashayan , N , Parsons , M T , Pejovic , T , Penney , K L , Peters , W H M , Phelan , C M , Phipps , A I , Plaseska-Karanfilska , D , Pring , M , Prokofyeva , D , Radice , P , Stefansson , K , Ramus , S J , Raskin , L , Rennert , G , Rennert , H S , van Rensburg , E J , Riggan , M J , Risch , H A , Risch , A , Roobol , M J , Rosenstein , B S , Rossing , M A , De Ruyck , K , Saloustros , E , Sandler , D P , Sawyer , E J , Schabath , M B , Schleutker , J , Schmidt , M K , Setiawan , V W , Shen , H , Siegel , E M , Sieh , W , Singer , C F , Slattery , M L , Sorensen , K D , Southey , M C , Spurdle , A B , Stanford , J L , Stevens , V L , Stintzing , S , Stone , J , Sundfeldt , K , Sutphen , R , Swerdlow , A J , Tajara , E H , Tangen , C M , Tardon , A , Taylor , J A , Teare , M D , Teixeira , M R , Terry , M B , Terry , K L , Thibodeau , S N , Thomassen , M , Bjørge , L , Tischkowitz , M , Toland , A E , Torres , D , Townsend , P A , Travis , R C , Tung , N , Tworoger , S S , Ulrich , C M , Usmani , N , Vachon , C M , Van Nieuwenhuysen , E , Vega , A , Aguado-Barrera , M E , Wang , Q , Webb , P M , Weinberg , C R , Weinstein , S , Weissler , M C , Weitzel , J N , West , C M L , White , E , Whittemore , A S , Wichmann , H E , Wiklund , F , Winqvist , R , Wolk , A , Woll , P , Woods , M , Wu , A H , Wu , X , Yannoukakos , D , Zheng , W , Zienolddiny , S , Ziogas , A , Zorn , K K , Lane , J M , Saxena , R , Thomas , D , Hung , R J , Diergaarde , B , McKay , J , Peters , U , Hsu , L , García-Closas , M , Eeles , R A , Chenevix-Trench , G , Brennan , P J , Haiman , C A , Simard , J , Easton , D F , Gruber , S B , Pharoah , P D P , Price , A L , Pasaniuc , B , Amos , C I , Kraft , P & Lindström , S 2019 , ' Shared heritability and functional enrichment across six solid cancers ' , Nature Communications , vol. 10 , no. 1 , 431 . https://doi.org/10.1038/s41467-018-08054-4 |
| Abstract: | Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. |
| DOI: | 10.1038/s41467-018-08054-4 |
| ISSN: | 2041-1723 |
| Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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