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10.1038/s41467-018-08054-4
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DC Field | Value | Language |
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dc.contributor.author | Jiang, Xia | - |
dc.contributor.author | Finucane, Hilary K. | - |
dc.contributor.author | Schumacher, Fredrick R. | - |
dc.contributor.author | Schmit, Stephanie L. | - |
dc.contributor.author | Tyrer, Jonathan P. | - |
dc.contributor.author | Han, Younghun | - |
dc.contributor.author | Michailidou, Kyriaki | - |
dc.contributor.author | Lesseur, Corina | - |
dc.contributor.author | Kuchenbaecker, Karoline B. | - |
dc.contributor.author | Dennis, Joe | - |
dc.contributor.author | Conti, David V. | - |
dc.contributor.author | Casey, Graham | - |
dc.contributor.author | Gaudet, Mia M. | - |
dc.contributor.author | Huyghe, Jeroen R. | - |
dc.contributor.author | Albanes, Demetrius | - |
dc.contributor.author | Aldrich, Melinda C. | - |
dc.contributor.author | Andrew, Angeline S. | - |
dc.contributor.author | Andrulis, Irene L. | - |
dc.contributor.author | Anton-Culver, Hoda | - |
dc.contributor.author | Antoniou, Antonis C. | - |
dc.contributor.author | Antonenkova, Natalia N. | - |
dc.contributor.author | Arnold, Susanne M. | - |
dc.contributor.author | Aronson, Kristan J. | - |
dc.contributor.author | Arun, Banu K. | - |
dc.contributor.author | Bandera, Elisa V. | - |
dc.contributor.author | Barkardottir, Rosa B. | - |
dc.contributor.author | Barnes, Daniel R. | - |
dc.contributor.author | Batra, Jyotsna | - |
dc.contributor.author | Beckmann, Matthias W. | - |
dc.contributor.author | Benitez, Javier | - |
dc.contributor.author | Benlloch, Sara | - |
dc.contributor.author | Berchuck, Andrew | - |
dc.contributor.author | Berndt, Sonja I. | - |
dc.contributor.author | Bickeböller, Heike | - |
dc.contributor.author | Bien, Stephanie A. | - |
dc.contributor.author | Blomqvist, Carl | - |
dc.contributor.author | Boccia, Stefania | - |
dc.contributor.author | Bogdanova, Natalia V. | - |
dc.contributor.author | Bojesen, Stig E. | - |
dc.contributor.author | Bolla, Manjeet K. | - |
dc.contributor.author | Brauch, Hiltrud | - |
dc.contributor.author | Brenner, Hermann | - |
dc.contributor.author | Brenton, James D. | - |
dc.contributor.author | Brook, Mark N. | - |
dc.contributor.author | Brunet, Joan | - |
dc.contributor.author | Brunnström, Hans | - |
dc.contributor.author | Buchanan, Daniel D. | - |
dc.contributor.author | Burwinkel, Barbara | - |
dc.contributor.author | Butzow, Ralf | - |
dc.contributor.author | Cadoni, Gabriella | - |
dc.contributor.author | Caldés, Trinidad | - |
dc.contributor.author | Caligo, Maria A. | - |
dc.contributor.author | Campbell, Ian | - |
dc.contributor.author | Campbell, Peter T. | - |
dc.contributor.author | Cancel-Tassin, Géraldine | - |
dc.contributor.author | Cannon-Albright, Lisa | - |
dc.contributor.author | Campa, Daniele | - |
dc.contributor.author | Caporaso, Neil | - |
dc.contributor.author | Carvalho, André L. | - |
dc.contributor.author | Chan, Andrew T. | - |
dc.contributor.author | Chang-Claude, Jenny | - |
dc.contributor.author | Chanock, Stephen J. | - |
dc.contributor.author | Chen, Chu | - |
dc.contributor.author | Christiani, David C. | - |
dc.contributor.author | Claes, Kathleen B.M. | - |
dc.contributor.author | Claessens, Frank | - |
dc.contributor.author | Clements, Judith | - |
dc.contributor.author | Collée, J. Margriet | - |
dc.contributor.author | Correa, Marcia Cruz | - |
dc.contributor.author | Couch, Fergus J. | - |
dc.contributor.author | Cox, Angela | - |
dc.contributor.author | Cunningham, Julie M. | - |
dc.contributor.author | Cybulski, Cezary | - |
dc.contributor.author | Czene, Kamila | - |
dc.contributor.author | Daly, Mary B. | - |
dc.contributor.author | deFazio, Anna | - |
dc.contributor.author | Devilee, Peter | - |
dc.contributor.author | Diez, Orland | - |
dc.contributor.author | Gago-Dominguez, Manuela | - |
dc.contributor.author | Donovan, Jenny L. | - |
dc.contributor.author | Dörk, Thilo | - |
dc.contributor.author | Duell, Eric J. | - |
dc.contributor.author | Dunning, Alison M. | - |
dc.contributor.author | Dwek, Miriam | - |
dc.contributor.author | Eccles, Diana M. | - |
dc.contributor.author | Edlund, Christopher K. | - |
dc.contributor.author | Edwards, Digna R.Velez | - |
dc.contributor.author | Ellberg, Carolina | - |
dc.contributor.author | Evans, D. Gareth | - |
dc.contributor.author | Fasching, Peter A. | - |
dc.contributor.author | Ferris, Robert L. | - |
dc.contributor.author | Liloglou, Triantafillos | - |
dc.contributor.author | Figueiredo, Jane C. | - |
dc.contributor.author | Fletcher, Olivia | - |
dc.contributor.author | Fortner, Renée T. | - |
dc.contributor.author | Fostira, Florentia | - |
dc.contributor.author | Franceschi, Silvia | - |
dc.contributor.author | Friedman, Eitan | - |
dc.contributor.author | Gallinger, Steven J. | - |
dc.contributor.author | Ganz, Patricia A. | - |
dc.contributor.author | Garber, Judy | - |
dc.contributor.author | García-Sáenz, José A. | - |
dc.contributor.author | Gayther, Simon A. | - |
dc.contributor.author | Giles, Graham G. | - |
dc.contributor.author | Godwin, Andrew K. | - |
dc.contributor.author | Goldberg, Mark S. | - |
dc.contributor.author | Goldgar, David E. | - |
dc.contributor.author | Goode, Ellen L. | - |
dc.contributor.author | Goodman, Marc T. | - |
dc.contributor.author | Goodman, Gary | - |
dc.contributor.author | Grankvist, Kjell | - |
dc.contributor.author | Greene, Mark H. | - |
dc.contributor.author | Gronberg, Henrik | - |
dc.contributor.author | Gronwald, Jacek | - |
dc.contributor.author | Guénel, Pascal | - |
dc.contributor.author | Håkansson, Niclas | - |
dc.contributor.author | Hall, Per | - |
dc.contributor.author | Hamann, Ute | - |
dc.contributor.author | Hamdy, Freddie C. | - |
dc.contributor.author | Hamilton, Robert J. | - |
dc.contributor.author | Hampe, Jochen | - |
dc.contributor.author | Haugen, Aage | - |
dc.contributor.author | Heitz, Florian | - |
dc.contributor.author | Herrero, Rolando | - |
dc.contributor.author | Hillemanns, Peter | - |
dc.contributor.author | Hoffmeister, Michael | - |
dc.contributor.author | Høgdall, Estrid | - |
dc.contributor.author | Hong, Yun Chul | - |
dc.contributor.author | Hopper, John L. | - |
dc.contributor.author | Houlston, Richard | - |
dc.contributor.author | Hulick, Peter J. | - |
dc.contributor.author | Hunter, David J. | - |
dc.contributor.author | Huntsman, David G. | - |
dc.contributor.author | Idos, Gregory | - |
dc.contributor.author | Imyanitov, Evgeny N. | - |
dc.contributor.author | Ingles, Sue Ann | - |
dc.contributor.author | Isaacs, Claudine | - |
dc.contributor.author | Jakubowska, Anna | - |
dc.contributor.author | James, Paul | - |
dc.contributor.author | Jenkins, Mark A. | - |
dc.contributor.author | Johansson, Mattias | - |
dc.contributor.author | Johansson, Mikael | - |
dc.contributor.author | John, Esther M. | - |
dc.contributor.author | Joshi, Amit D. | - |
dc.contributor.author | Kaneva, Radka | - |
dc.contributor.author | Karlan, Beth Y. | - |
dc.contributor.author | Kelemen, Linda E. | - |
dc.contributor.author | Kühl, Tabea | - |
dc.contributor.author | Khaw, Kay Tee | - |
dc.contributor.author | Khusnutdinova, Elza | - |
dc.contributor.author | Kibel, Adam S. | - |
dc.contributor.author | Kiemeney, Lambertus A. | - |
dc.contributor.author | Kim, Jeri | - |
dc.contributor.author | Kjaer, Susanne K. | - |
dc.contributor.author | Knight, Julia A. | - |
dc.contributor.author | Kogevinas, Manolis | - |
dc.contributor.author | Kote-Jarai, Zsofia | - |
dc.contributor.author | Koutros, Stella | - |
dc.contributor.author | Kristensen, Vessela N. | - |
dc.contributor.author | Kupryjanczyk, Jolanta | - |
dc.contributor.author | Lacko, Martin | - |
dc.contributor.author | Lam, Stephan | - |
dc.contributor.author | Lambrechts, Diether | - |
dc.contributor.author | Landi, Maria Teresa | - |
dc.contributor.author | Lazarus, Philip | - |
dc.contributor.author | Le, Nhu D. | - |
dc.contributor.author | Lee, Eunjung | - |
dc.contributor.author | Lejbkowicz, Flavio | - |
dc.contributor.author | Lenz, Heinz Josef | - |
dc.contributor.author | Leslie, Goska | - |
dc.contributor.author | Lessel, Davor | - |
dc.contributor.author | Lester, Jenny | - |
dc.contributor.author | Levine, Douglas A. | - |
dc.contributor.author | Li, Li | - |
dc.contributor.author | Li, Christopher I. | - |
dc.contributor.author | Lindblom, Annika | - |
dc.contributor.author | Lindor, Noralane M. | - |
dc.contributor.author | Liu, Geoffrey | - |
dc.contributor.author | Loupakis, Fotios | - |
dc.contributor.author | Lubiński, Jan | - |
dc.contributor.author | Maehle, Lovise | - |
dc.contributor.author | Maier, Christiane | - |
dc.contributor.author | Mannermaa, Arto | - |
dc.contributor.author | Marchand, Loic Le | - |
dc.contributor.author | Margolin, Sara | - |
dc.contributor.author | May, Taymaa | - |
dc.contributor.author | McGuffog, Lesley | - |
dc.contributor.author | Meindl, Alfons | - |
dc.contributor.author | Middha, Pooja | - |
dc.contributor.author | Miller, Austin | - |
dc.contributor.author | Milne, Roger L. | - |
dc.contributor.author | MacInnis, Robert J. | - |
dc.contributor.author | Modugno, Francesmary | - |
dc.contributor.author | Montagna, Marco | - |
dc.contributor.author | Moreno, Victor | - |
dc.contributor.author | Moysich, Kirsten B. | - |
dc.contributor.author | Mucci, Lorelei | - |
dc.contributor.author | Muir, Kenneth | - |
dc.contributor.author | Mulligan, Anna Marie | - |
dc.contributor.author | Nathanson, Katherine L. | - |
dc.contributor.author | Neal, David E. | - |
dc.contributor.author | Ness, Andrew R. | - |
dc.contributor.author | Neuhausen, Susan L. | - |
dc.contributor.author | Nevanlinna, Heli | - |
dc.contributor.author | Newcomb, Polly A. | - |
dc.contributor.author | Newcomb, Lisa F. | - |
dc.contributor.author | Nielsen, Finn Cilius | - |
dc.contributor.author | Nikitina-Zake, Liene | - |
dc.contributor.author | Nordestgaard, Børge G. | - |
dc.contributor.author | Nussbaum, Robert L. | - |
dc.contributor.author | Offit, Kenneth | - |
dc.contributor.author | Olah, Edith | - |
dc.contributor.author | Olama, Ali Amin Al | - |
dc.contributor.author | Olopade, Olufunmilayo I. | - |
dc.contributor.author | Olshan, Andrew F. | - |
dc.contributor.author | Olsson, Håkan | - |
dc.contributor.author | Osorio, Ana | - |
dc.contributor.author | Pandha, Hardev | - |
dc.contributor.author | Park, Jong Y. | - |
dc.contributor.author | Pashayan, Nora | - |
dc.contributor.author | Parsons, Michael T. | - |
dc.contributor.author | Pejovic, Tanja | - |
dc.contributor.author | Penney, Kathryn L. | - |
dc.contributor.author | Peters, Wilbert H.M. | - |
dc.contributor.author | Phelan, Catherine M. | - |
dc.contributor.author | Phipps, Amanda I. | - |
dc.contributor.author | Plaseska-Karanfilska, Dijana | - |
dc.contributor.author | Pring, Miranda | - |
dc.contributor.author | Prokofyeva, Darya | - |
dc.contributor.author | Radice, Paolo | - |
dc.contributor.author | Stefansson, Kari | - |
dc.contributor.author | Ramus, Susan J. | - |
dc.contributor.author | Raskin, Leon | - |
dc.contributor.author | Rennert, Gad | - |
dc.contributor.author | Rennert, Hedy S. | - |
dc.contributor.author | van Rensburg, Elizabeth J. | - |
dc.contributor.author | Riggan, Marjorie J. | - |
dc.contributor.author | Risch, Harvey A. | - |
dc.contributor.author | Risch, Angela | - |
dc.contributor.author | Roobol, Monique J. | - |
dc.contributor.author | Rosenstein, Barry S. | - |
dc.contributor.author | Rossing, Mary Anne | - |
dc.contributor.author | De Ruyck, Kim | - |
dc.contributor.author | Saloustros, Emmanouil | - |
dc.contributor.author | Sandler, Dale P. | - |
dc.contributor.author | Sawyer, Elinor J. | - |
dc.contributor.author | Schabath, Matthew B. | - |
dc.contributor.author | Schleutker, Johanna | - |
dc.contributor.author | Schmidt, Marjanka K. | - |
dc.contributor.author | Setiawan, V. Wendy | - |
dc.contributor.author | Shen, Hongbing | - |
dc.contributor.author | Siegel, Erin M. | - |
dc.contributor.author | Sieh, Weiva | - |
dc.contributor.author | Singer, Christian F. | - |
dc.contributor.author | Slattery, Martha L. | - |
dc.contributor.author | Sorensen, Karina Dalsgaard | - |
dc.contributor.author | Southey, Melissa C. | - |
dc.contributor.author | Spurdle, Amanda B. | - |
dc.contributor.author | Stanford, Janet L. | - |
dc.contributor.author | Stevens, Victoria L. | - |
dc.contributor.author | Stintzing, Sebastian | - |
dc.contributor.author | Stone, Jennifer | - |
dc.contributor.author | Sundfeldt, Karin | - |
dc.contributor.author | Sutphen, Rebecca | - |
dc.contributor.author | Swerdlow, Anthony J. | - |
dc.contributor.author | Tajara, Eloiza H. | - |
dc.contributor.author | Tangen, Catherine M. | - |
dc.contributor.author | Tardon, Adonina | - |
dc.contributor.author | Taylor, Jack A. | - |
dc.contributor.author | Teare, M. Dawn | - |
dc.contributor.author | Teixeira, Manuel R. | - |
dc.contributor.author | Terry, Mary Beth | - |
dc.contributor.author | Terry, Kathryn L. | - |
dc.contributor.author | Thibodeau, Stephen N. | - |
dc.contributor.author | Thomassen, Mads | - |
dc.contributor.author | Bjørge, Line | - |
dc.contributor.author | Tischkowitz, Marc | - |
dc.contributor.author | Toland, Amanda E. | - |
dc.contributor.author | Torres, Diana | - |
dc.contributor.author | Townsend, Paul A. | - |
dc.contributor.author | Travis, Ruth C. | - |
dc.contributor.author | Tung, Nadine | - |
dc.contributor.author | Tworoger, Shelley S. | - |
dc.contributor.author | Ulrich, Cornelia M. | - |
dc.contributor.author | Usmani, Nawaid | - |
dc.contributor.author | Vachon, Celine M. | - |
dc.contributor.author | Van Nieuwenhuysen, Els | - |
dc.contributor.author | Vega, Ana | - |
dc.contributor.author | Aguado-Barrera, Miguel Elías | - |
dc.contributor.author | Wang, Qin | - |
dc.contributor.author | Webb, Penelope M. | - |
dc.contributor.author | Weinberg, Clarice R. | - |
dc.contributor.author | Weinstein, Stephanie | - |
dc.contributor.author | Weissler, Mark C. | - |
dc.contributor.author | Weitzel, Jeffrey N. | - |
dc.contributor.author | West, Catharine M.L. | - |
dc.contributor.author | White, Emily | - |
dc.contributor.author | Whittemore, Alice S. | - |
dc.contributor.author | Wichmann, H. Erich | - |
dc.contributor.author | Wiklund, Fredrik | - |
dc.contributor.author | Winqvist, Robert | - |
dc.contributor.author | Wolk, Alicja | - |
dc.contributor.author | Woll, Penella | - |
dc.contributor.author | Woods, Michael | - |
dc.contributor.author | Wu, Anna H. | - |
dc.contributor.author | Wu, Xifeng | - |
dc.contributor.author | Yannoukakos, Drakoulis | - |
dc.contributor.author | Zheng, Wei | - |
dc.contributor.author | Zienolddiny, Shanbeh | - |
dc.contributor.author | Ziogas, Argyrios | - |
dc.contributor.author | Zorn, Kristin K. | - |
dc.contributor.author | Lane, Jacqueline M. | - |
dc.contributor.author | Saxena, Richa | - |
dc.contributor.author | Thomas, Duncan | - |
dc.contributor.author | Hung, Rayjean J. | - |
dc.contributor.author | Diergaarde, Brenda | - |
dc.contributor.author | McKay, James | - |
dc.contributor.author | Peters, Ulrike | - |
dc.contributor.author | Hsu, Li | - |
dc.contributor.author | García-Closas, Montserrat | - |
dc.contributor.author | Eeles, Rosalind A. | - |
dc.contributor.author | Chenevix-Trench, Georgia | - |
dc.contributor.author | Brennan, Paul J. | - |
dc.contributor.author | Haiman, Christopher A. | - |
dc.contributor.author | Simard, Jacques | - |
dc.contributor.author | Easton, Douglas F. | - |
dc.contributor.author | Gruber, Stephen B. | - |
dc.contributor.author | Pharoah, Paul D.P. | - |
dc.contributor.author | Price, Alkes L. | - |
dc.contributor.author | Pasaniuc, Bogdan | - |
dc.contributor.author | Amos, Christopher I. | - |
dc.contributor.author | Kraft, Peter | - |
dc.contributor.author | Lindström, Sara | - |
dc.date.accessioned | 2021-04-13T14:25:01Z | - |
dc.date.available | 2021-04-13T14:25:01Z | - |
dc.date.issued | 2019-12-01 | - |
dc.identifier.citation | Jiang , X , Finucane , H K , Schumacher , F R , Schmit , S L , Tyrer , J P , Han , Y , Michailidou , K , Lesseur , C , Kuchenbaecker , K B , Dennis , J , Conti , D V , Casey , G , Gaudet , M M , Huyghe , J R , Albanes , D , Aldrich , M C , Andrew , A S , Andrulis , I L , Anton-Culver , H , Antoniou , A C , Antonenkova , N N , Arnold , S M , Aronson , K J , Arun , B K , Bandera , E V , Barkardottir , R B , Barnes , D R , Batra , J , Beckmann , M W , Benitez , J , Benlloch , S , Berchuck , A , Berndt , S I , Bickeböller , H , Bien , S A , Blomqvist , C , Boccia , S , Bogdanova , N V , Bojesen , S E , Bolla , M K , Brauch , H , Brenner , H , Brenton , J D , Brook , M N , Brunet , J , Brunnström , H , Buchanan , D D , Burwinkel , B , Butzow , R , Cadoni , G , Caldés , T , Caligo , M A , Campbell , I , Campbell , P T , Cancel-Tassin , G , Cannon-Albright , L , Campa , D , Caporaso , N , Carvalho , A L , Chan , A T , Chang-Claude , J , Chanock , S J , Chen , C , Christiani , D C , Claes , K B M , Claessens , F , Clements , J , Collée , J M , Correa , M C , Couch , F J , Cox , A , Cunningham , J M , Cybulski , C , Czene , K , Daly , M B , deFazio , A , Devilee , P , Diez , O , Gago-Dominguez , M , Donovan , J L , Dörk , T , Duell , E J , Dunning , A M , Dwek , M , Eccles , D M , Edlund , C K , Edwards , D R V , Ellberg , C , Evans , D G , Fasching , P A , Ferris , R L , Liloglou , T , Figueiredo , J C , Fletcher , O , Fortner , R T , Fostira , F , Franceschi , S , Friedman , E , Gallinger , S J , Ganz , P A , Garber , J , García-Sáenz , J A , Gayther , S A , Giles , G G , Godwin , A K , Goldberg , M S , Goldgar , D E , Goode , E L , Goodman , M T , Goodman , G , Grankvist , K , Greene , M H , Gronberg , H , Gronwald , J , Guénel , P , Håkansson , N , Hall , P , Hamann , U , Hamdy , F C , Hamilton , R J , Hampe , J , Haugen , A , Heitz , F , Herrero , R , Hillemanns , P , Hoffmeister , M , Høgdall , E , Hong , Y C , Hopper , J L , Houlston , R , Hulick , P J , Hunter , D J , Huntsman , D G , Idos , G , Imyanitov , E N , Ingles , S A , Isaacs , C , Jakubowska , A , James , P , Jenkins , M A , Johansson , M , Johansson , M , John , E M , Joshi , A D , Kaneva , R , Karlan , B Y , Kelemen , L E , Kühl , T , Khaw , K T , Khusnutdinova , E , Kibel , A S , Kiemeney , L A , Kim , J , Kjaer , S K , Knight , J A , Kogevinas , M , Kote-Jarai , Z , Koutros , S , Kristensen , V N , Kupryjanczyk , J , Lacko , M , Lam , S , Lambrechts , D , Landi , M T , Lazarus , P , Le , N D , Lee , E , Lejbkowicz , F , Lenz , H J , Leslie , G , Lessel , D , Lester , J , Levine , D A , Li , L , Li , C I , Lindblom , A , Lindor , N M , Liu , G , Loupakis , F , Lubiński , J , Maehle , L , Maier , C , Mannermaa , A , Marchand , L L , Margolin , S , May , T , McGuffog , L , Meindl , A , Middha , P , Miller , A , Milne , R L , MacInnis , R J , Modugno , F , Montagna , M , Moreno , V , Moysich , K B , Mucci , L , Muir , K , Mulligan , A M , Nathanson , K L , Neal , D E , Ness , A R , Neuhausen , S L , Nevanlinna , H , Newcomb , P A , Newcomb , L F , Nielsen , F C , Nikitina-Zake , L , Nordestgaard , B G , Nussbaum , R L , Offit , K , Olah , E , Olama , A A A , Olopade , O I , Olshan , A F , Olsson , H , Osorio , A , Pandha , H , Park , J Y , Pashayan , N , Parsons , M T , Pejovic , T , Penney , K L , Peters , W H M , Phelan , C M , Phipps , A I , Plaseska-Karanfilska , D , Pring , M , Prokofyeva , D , Radice , P , Stefansson , K , Ramus , S J , Raskin , L , Rennert , G , Rennert , H S , van Rensburg , E J , Riggan , M J , Risch , H A , Risch , A , Roobol , M J , Rosenstein , B S , Rossing , M A , De Ruyck , K , Saloustros , E , Sandler , D P , Sawyer , E J , Schabath , M B , Schleutker , J , Schmidt , M K , Setiawan , V W , Shen , H , Siegel , E M , Sieh , W , Singer , C F , Slattery , M L , Sorensen , K D , Southey , M C , Spurdle , A B , Stanford , J L , Stevens , V L , Stintzing , S , Stone , J , Sundfeldt , K , Sutphen , R , Swerdlow , A J , Tajara , E H , Tangen , C M , Tardon , A , Taylor , J A , Teare , M D , Teixeira , M R , Terry , M B , Terry , K L , Thibodeau , S N , Thomassen , M , Bjørge , L , Tischkowitz , M , Toland , A E , Torres , D , Townsend , P A , Travis , R C , Tung , N , Tworoger , S S , Ulrich , C M , Usmani , N , Vachon , C M , Van Nieuwenhuysen , E , Vega , A , Aguado-Barrera , M E , Wang , Q , Webb , P M , Weinberg , C R , Weinstein , S , Weissler , M C , Weitzel , J N , West , C M L , White , E , Whittemore , A S , Wichmann , H E , Wiklund , F , Winqvist , R , Wolk , A , Woll , P , Woods , M , Wu , A H , Wu , X , Yannoukakos , D , Zheng , W , Zienolddiny , S , Ziogas , A , Zorn , K K , Lane , J M , Saxena , R , Thomas , D , Hung , R J , Diergaarde , B , McKay , J , Peters , U , Hsu , L , García-Closas , M , Eeles , R A , Chenevix-Trench , G , Brennan , P J , Haiman , C A , Simard , J , Easton , D F , Gruber , S B , Pharoah , P D P , Price , A L , Pasaniuc , B , Amos , C I , Kraft , P & Lindström , S 2019 , ' Shared heritability and functional enrichment across six solid cancers ' , Nature Communications , vol. 10 , no. 1 , 431 . https://doi.org/10.1038/s41467-018-08054-4 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.other | Mendeley: bc73843b-12b3-3478-928f-84d194ed382c | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/3793 | - |
dc.description.abstract | Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. | en |
dc.format.extent | 3921228 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Nature Communications | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Shared heritability and functional enrichment across six solid cancers | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1038/s41467-018-08054-4 | - |
dc.identifier.url | https://www.mendeley.com/catalogue/bc73843b-12b3-3478-928f-84d194ed382c/ | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Shared_heritability_and_functional_enrichment.pdf | 3.83 MB | Adobe PDF | View/Open |
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