Please use this identifier to cite or link to this item:
10.1016/j.ijbiomac.2024.135703
Title: | Injectable mineralized Sr-hydroxyapatite nanoparticles-loaded ɛ-polylysine-hyaluronic acid composite hydrogels for bone regeneration |
Authors: | Rubina, A. Sceglovs, Artemijs Ramata-Stunda, Anna Pugajeva, Iveta Skadiņš, Ingus Boyd, A. R. Tumilovica, A. Stīpniece, Līga Salma-Ancane, K. Department of Biology and Microbiology |
Keywords: | Antibacterial hydrogels;Injectable nanocomposite hydrogels;Osteogenic potential;Sr ion delivery;Sr-substituted hydroxyapatite nanoparticles;1.6 Biological sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;Structural Biology;Biochemistry;Molecular Biology |
Issue Date: | Nov-2024 |
Citation: | Rubina , A , Sceglovs , A , Ramata-Stunda , A , Pugajeva , I , Skadiņš , I , Boyd , A R , Tumilovica , A , Stīpniece , L & Salma-Ancane , K 2024 , ' Injectable mineralized Sr-hydroxyapatite nanoparticles-loaded ɛ-polylysine-hyaluronic acid composite hydrogels for bone regeneration ' , International Journal of Biological Macromolecules , vol. 280 , no. 1 , 135703 . https://doi.org/10.1016/j.ijbiomac.2024.135703 |
Abstract: | In this study, multifunctional injectable mineralized antibacterial nanocomposite hydrogels were prepared by a homogenous distribution of high content of (up to 60 wt%) Sr-substituted hydroxyapatite (Sr-HAp) nanoparticles into covalently cross-linked ɛ-polylysine (ɛ-PL) and hyaluronic acid (HA) hydrogel network. The developed bone-targeted nanocomposite hydrogels were to synergistically combine the functional properties of bioactive Sr-HAp nanoparticles and antibacterial ɛ-PL-HA hydrogels for bone tissue regeneration. Viscoelasticity, injectability, structural parameters, degradation, antibacterial activity, and in vitro biocompatibility of the fabricated nanocomposite hydrogels were characterized. Physical performances of the ɛ-PL-HA hydrogels can be tailored by altering the mass ratio of Sr-HAp. The nanocomposite hydrogels revealed good stability against enzymatic degradation, which increased from 5 to 19 weeks with increasing the mass ratio of Sr-HAp from 40 % to 60 %. The loading of the Sr-HAp at relatively high mass ratios did not suppress the fast-acting and long-term antibacterial activity of the ɛ-PL-HA hydrogels against S. aureus and E. coli. The cell studies confirmed the cytocompatibility and pre-collagen I synthesis-promoting activity of the fabricated nanocomposite hydrogels. |
Description: | Publisher Copyright: © 2024 The Authors |
DOI: | 10.1016/j.ijbiomac.2024.135703 |
ISSN: | 0141-8130 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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File | Size | Format | |
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Injectable_mineralized_Sr-hydroxyapatite_nanoparticles.pdf | 17.64 MB | Adobe PDF | View/Open |
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