Please use this identifier to cite or link to this item:
10.1016/j.ijbiomac.2024.135703
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DC Field | Value | Language |
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dc.contributor.author | Rubina, A. | - |
dc.contributor.author | Sceglovs, Artemijs | - |
dc.contributor.author | Ramata-Stunda, Anna | - |
dc.contributor.author | Pugajeva, Iveta | - |
dc.contributor.author | Skadiņš, Ingus | - |
dc.contributor.author | Boyd, A. R. | - |
dc.contributor.author | Tumilovica, A. | - |
dc.contributor.author | Stīpniece, Līga | - |
dc.contributor.author | Salma-Ancane, K. | - |
dc.date.accessioned | 2024-09-26T10:35:01Z | - |
dc.date.available | 2024-09-26T10:35:01Z | - |
dc.date.issued | 2024-11 | - |
dc.identifier.citation | Rubina , A , Sceglovs , A , Ramata-Stunda , A , Pugajeva , I , Skadiņš , I , Boyd , A R , Tumilovica , A , Stīpniece , L & Salma-Ancane , K 2024 , ' Injectable mineralized Sr-hydroxyapatite nanoparticles-loaded ɛ-polylysine-hyaluronic acid composite hydrogels for bone regeneration ' , International Journal of Biological Macromolecules , vol. 280 , no. 1 , 135703 . https://doi.org/10.1016/j.ijbiomac.2024.135703 | - |
dc.identifier.issn | 0141-8130 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/16713 | - |
dc.description | Publisher Copyright: © 2024 The Authors | - |
dc.description.abstract | In this study, multifunctional injectable mineralized antibacterial nanocomposite hydrogels were prepared by a homogenous distribution of high content of (up to 60 wt%) Sr-substituted hydroxyapatite (Sr-HAp) nanoparticles into covalently cross-linked ɛ-polylysine (ɛ-PL) and hyaluronic acid (HA) hydrogel network. The developed bone-targeted nanocomposite hydrogels were to synergistically combine the functional properties of bioactive Sr-HAp nanoparticles and antibacterial ɛ-PL-HA hydrogels for bone tissue regeneration. Viscoelasticity, injectability, structural parameters, degradation, antibacterial activity, and in vitro biocompatibility of the fabricated nanocomposite hydrogels were characterized. Physical performances of the ɛ-PL-HA hydrogels can be tailored by altering the mass ratio of Sr-HAp. The nanocomposite hydrogels revealed good stability against enzymatic degradation, which increased from 5 to 19 weeks with increasing the mass ratio of Sr-HAp from 40 % to 60 %. The loading of the Sr-HAp at relatively high mass ratios did not suppress the fast-acting and long-term antibacterial activity of the ɛ-PL-HA hydrogels against S. aureus and E. coli. The cell studies confirmed the cytocompatibility and pre-collagen I synthesis-promoting activity of the fabricated nanocomposite hydrogels. | en |
dc.format.extent | 22 | - |
dc.format.extent | 18063811 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | International Journal of Biological Macromolecules | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Antibacterial hydrogels | - |
dc.subject | Injectable nanocomposite hydrogels | - |
dc.subject | Osteogenic potential | - |
dc.subject | Sr ion delivery | - |
dc.subject | Sr-substituted hydroxyapatite nanoparticles | - |
dc.subject | 1.6 Biological sciences | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Structural Biology | - |
dc.subject | Biochemistry | - |
dc.subject | Molecular Biology | - |
dc.title | Injectable mineralized Sr-hydroxyapatite nanoparticles-loaded ɛ-polylysine-hyaluronic acid composite hydrogels for bone regeneration | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1016/j.ijbiomac.2024.135703 | - |
dc.contributor.institution | Department of Biology and Microbiology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85204225519&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Injectable_mineralized_Sr-hydroxyapatite_nanoparticles.pdf | 17.64 MB | Adobe PDF | View/Open |
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