Please use this identifier to cite or link to this item:
10.3390/jcm13144225
Title: | From Biomechanical Properties to Morphological Variations : Exploring the Interplay between Aortic Valve Cuspidity and Ascending Aortic Aneurysm |
Authors: | Brečs, Ivars Skuja, Sandra Kasyanov, Vladimir Groma, Valērija Kalējs, Mārtiņš Svirskis, Šimons Ozolanta, Iveta Stradiņš, Pēteris Joint Laboratory of Electron Microscopy Joint Laboratory of Traumatology and Orthopaedics Faculty of Medicine Institute of Microbiology and Virology |
Keywords: | tricuspid aortic valve;bicuspid aortic valve;ascending thoracic aortic aneurysm;biomechanical properties;morphology;3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database |
Issue Date: | 19-Jul-2024 |
Citation: | Brečs , I , Skuja , S , Kasyanov , V , Groma , V , Kalējs , M , Svirskis , Š , Ozolanta , I & Stradiņš , P 2024 , ' From Biomechanical Properties to Morphological Variations : Exploring the Interplay between Aortic Valve Cuspidity and Ascending Aortic Aneurysm ' , Journal of clinical medicine , vol. 13 , no. 14 , 4225 . https://doi.org/10.3390/jcm13144225 |
Abstract: | Background: This research explores the biomechanical and structural characteristics of ascending thoracic aortic aneurysms (ATAAs), focusing on the differences between bicuspid aortic valve aneurysms (BAV-As) and tricuspid aortic valve aneurysms (TAV-As) with non-dilated aortas to identify specific traits of ATAAs. Methods: Clinical characteristics, laboratory indices, and imaging data from 26 adult patients operated on for aneurysms (BAV-A: n = 12; TAV-A: n = 14) and 13 controls were analyzed. Biomechanical parameters (maximal aortic diameter, strain, and stress) and structural analyses (collagen fiber organization, density, fragmentation, adipocyte deposits, and immune cell infiltration) were assessed. Results: Significant differences in biomechanical parameters were observed. Median maximal strain was 40.0% (control), 63.4% (BAV-A), and 45.3% (TAV-A); median maximal stress was 0.59 MPa (control), 0.78 MPa (BAV-A), and 0.48 MPa (TAV-A). BAV-A showed higher tangential modulus and smaller diameter, with substantial collagen fragmentation ( p < 0.001 vs. TAV and controls). TAV-A exhibited increased collagen density ( p = 0.025), thickening between media and adventitia layers, and disorganized fibers ( p = 0.036). BAV-A patients had elevated adipocyte deposits and immune cell infiltration. Conclusions: This study highlights distinct pathological profiles associated with different valve anatomies. BAV-A is characterized by smaller diameters, higher biomechanical stress, and significant collagen deterioration, underscoring the necessity for tailored clinical strategies for effective management of thoracic aortic aneurysm. |
DOI: | 10.3390/jcm13144225 |
ISSN: | 2077-0383 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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From_Biomechanical_Properties_to_Morphological_Variations.pdf | 53.24 MB | Adobe PDF | View/Open![]() |
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