Please use this identifier to cite or link to this item:
10.3390/jcm13144225
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DC Field | Value | Language |
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dc.contributor.author | Brečs, Ivars | - |
dc.contributor.author | Skuja, Sandra | - |
dc.contributor.author | Kasyanov, Vladimir | - |
dc.contributor.author | Groma, Valērija | - |
dc.contributor.author | Kalējs, Mārtiņš | - |
dc.contributor.author | Svirskis, Šimons | - |
dc.contributor.author | Ozolanta, Iveta | - |
dc.contributor.author | Stradiņš, Pēteris | - |
dc.date.accessioned | 2024-08-28T14:50:03Z | - |
dc.date.available | 2024-08-28T14:50:03Z | - |
dc.date.issued | 2024-07-19 | - |
dc.identifier.citation | Brečs , I , Skuja , S , Kasyanov , V , Groma , V , Kalējs , M , Svirskis , Š , Ozolanta , I & Stradiņš , P 2024 , ' From Biomechanical Properties to Morphological Variations : Exploring the Interplay between Aortic Valve Cuspidity and Ascending Aortic Aneurysm ' , Journal of clinical medicine , vol. 13 , no. 14 , 4225 . https://doi.org/10.3390/jcm13144225 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.other | PubMedCentral: PMC11277922 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/16617 | - |
dc.description.abstract | Background: This research explores the biomechanical and structural characteristics of ascending thoracic aortic aneurysms (ATAAs), focusing on the differences between bicuspid aortic valve aneurysms (BAV-As) and tricuspid aortic valve aneurysms (TAV-As) with non-dilated aortas to identify specific traits of ATAAs. Methods: Clinical characteristics, laboratory indices, and imaging data from 26 adult patients operated on for aneurysms (BAV-A: n = 12; TAV-A: n = 14) and 13 controls were analyzed. Biomechanical parameters (maximal aortic diameter, strain, and stress) and structural analyses (collagen fiber organization, density, fragmentation, adipocyte deposits, and immune cell infiltration) were assessed. Results: Significant differences in biomechanical parameters were observed. Median maximal strain was 40.0% (control), 63.4% (BAV-A), and 45.3% (TAV-A); median maximal stress was 0.59 MPa (control), 0.78 MPa (BAV-A), and 0.48 MPa (TAV-A). BAV-A showed higher tangential modulus and smaller diameter, with substantial collagen fragmentation ( p < 0.001 vs. TAV and controls). TAV-A exhibited increased collagen density ( p = 0.025), thickening between media and adventitia layers, and disorganized fibers ( p = 0.036). BAV-A patients had elevated adipocyte deposits and immune cell infiltration. Conclusions: This study highlights distinct pathological profiles associated with different valve anatomies. BAV-A is characterized by smaller diameters, higher biomechanical stress, and significant collagen deterioration, underscoring the necessity for tailored clinical strategies for effective management of thoracic aortic aneurysm. | en |
dc.format.extent | 25 | - |
dc.format.extent | 54521251 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Journal of clinical medicine | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | tricuspid aortic valve | - |
dc.subject | bicuspid aortic valve | - |
dc.subject | ascending thoracic aortic aneurysm | - |
dc.subject | biomechanical properties | - |
dc.subject | morphology | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.title | From Biomechanical Properties to Morphological Variations : Exploring the Interplay between Aortic Valve Cuspidity and Ascending Aortic Aneurysm | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/jcm13144225 | - |
dc.contributor.institution | Joint Laboratory of Electron Microscopy | - |
dc.contributor.institution | Joint Laboratory of Traumatology and Orthopaedics | - |
dc.contributor.institution | Faculty of Medicine | - |
dc.contributor.institution | Institute of Microbiology and Virology | - |
dc.identifier.url | https://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/WOS:001278542000001 | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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From_Biomechanical_Properties_to_Morphological_Variations.pdf | 53.24 MB | Adobe PDF | View/Open![]() |
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