Please use this identifier to cite or link to this item:
10.3390/pharmaceutics16070945
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DC Field | Value | Language |
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dc.contributor.author | Paulausks, Artūrs | - |
dc.contributor.author | Kolisnyk, Tetiana | - |
dc.contributor.author | Mohylyuk, Valentyn | - |
dc.date.accessioned | 2024-07-24T06:40:02Z | - |
dc.date.available | 2024-07-24T06:40:02Z | - |
dc.date.issued | 2024-07-16 | - |
dc.identifier.citation | Paulausks , A , Kolisnyk , T & Mohylyuk , V 2024 , ' The Increase in the Plasticity of Microcrystalline Cellulose Spheres’ When Loaded with a Plasticizer ' , Pharmaceutics , vol. 16 , no. 7 , 945 . https://doi.org/10.3390/pharmaceutics16070945 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/16474 | - |
dc.description.abstract | Compaction pressure can induce an undesirable solid-state polymorphic transition in drugs, fragmentation, loss of coated pellet integrity, and the decreased viability and vitality of microorganisms. Thus, the excipients with increased plasticity can be considered as an option to decrease the undesirable effects of compaction pressure. This study aims to increase the plasticity (to reduce the mean yield pressure; Py) of dried microcrystalline cellulose (MCC) by loading it with a specially selected plasticizer. Diethyl citrate (DEC), water, and glycerol were the considered plasticizers. Computation of solubility parameters was used to predict the miscibility of MCC with plasticizers (possible plasticization effect). Plasticizer-loaded MCC spheres with 5.0 wt.% of water, 5.2 wt.% of DEC, and 4.2 wt.% glycerol were obtained via the solvent method, followed by solvent evaporation. Plasticizer-loaded formulations were characterised by TGA, DSC, pXRD, FTIR, pressure-displacement profiles, and in-die Heckel plots. Py was derived from the in-die Heckel analysis and was used as a plasticity parameter. In comparison with non-plasticized MCC (Py = 136.5 MPa), the plasticity of plasticizer-loaded formulations increased (and Py decreased) from DEC (124.7 MPa) to water (106.6 MPa) and glycerol (99.9 MPa), and that was in full accordance with the predicted miscibility likeliness order based on solubility parameters. Therefore, water and glycerol were able to decrease the Py of non-plasticized MCC spheres by 16.3 and 30.0%, respectively. This feasibility study showed the possibility of modifying the plasticity of MCC by loading it with a specially selected plasticizer. | en |
dc.format.extent | 5084335 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Pharmaceutics | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | tablets | - |
dc.subject | microcrystalline cellulose | - |
dc.subject | plasticizer | - |
dc.subject | glycerol | - |
dc.subject | yield pressure | - |
dc.subject | mean yield pressure | - |
dc.subject | solubility parameters | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions) | - |
dc.title | The Increase in the Plasticity of Microcrystalline Cellulose Spheres’ When Loaded with a Plasticizer | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/pharmaceutics16070945 | - |
dc.contributor.institution | Lead Researcher Group | - |
dc.identifier.url | https://www.mdpi.com/1999-4923/16/7/945 | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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pharmaceutics-16-00945.pdf | 4.97 MB | Adobe PDF | View/Open |
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