Please use this identifier to cite or link to this item:
10.3390/jcm12237291
Title: | Expression of p53, p63, p16, Ki67, Cyclin D, Bcl-2, and CD31 Markers in Actinic Keratosis, In Situ Squamous Cell Carcinoma and Normal Sun-Exposed Skin of Elderly Patients |
Authors: | Balcere, Alise Sperga, Māris Čēma, Ingrīda Lauskis, Gunārs Zolovs, Maksims Rone-Kupfere, Māra Krūmiņa, Angelika Department of Dermatology and Venereology Department of Oral and Maxillofacial Surgery and Oral Medicine Statistics Unit Department of Infectology |
Keywords: | age;UV damage;immunohistochemistry;cell cycle regulatory markers;skin cancer;3.2 Clinical medicine;4.1 Agriculture, Forestry, and Fisheries;4.3 Veterinary science;1.6 Biological sciences;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;SDG 3 - Good Health and Well-being |
Issue Date: | Dec-2023 |
Citation: | Balcere , A , Sperga , M , Čēma , I , Lauskis , G , Zolovs , M , Rone-Kupfere , M & Krūmiņa , A 2023 , ' Expression of p53, p63, p16, Ki67, Cyclin D, Bcl-2, and CD31 Markers in Actinic Keratosis, In Situ Squamous Cell Carcinoma and Normal Sun-Exposed Skin of Elderly Patients ' , Journal of Clinical Medicine , vol. 12 , no. 23 , 7291 . https://doi.org/10.3390/jcm12237291 |
Abstract: | Background: Age and cumulative exposure to ultraviolet (UV) light are primary contributors to skin cancer development. Regulatory proteins within the cell cycle are essential for the homeostasis of squamous epithelium. Methods: This study assessed the expression of immunohistochemical markers p53, p63, p16, Ki67, Cyclin D, Bcl-2, and CD31 in keratinocyte intraepithelial neoplasia (actinic keratosis and squamous cell carcinoma in situ) compared to normal skin. The objective was to distinguish disease-specific changes from those attributable to ageing and sun exposure in elderly skin. Results. Analysis included 22 actinic keratoses (AK), 7 in situ squamous cell carcinomas (SCC), and 8 normal skin biopsies. The mean age was 78.1 years for the AK/SCC group and 73.8 years for controls, with no significant age difference noted between the groups. The AK/SCC group exhibited a higher occurrence of amorphous masses, higher intensity of p53, lower Bcl-2 expression in the epidermis, higher Bcl-2 expression in the dermis, and higher CD31 expression in the dermis, all of which were statistically significant (p < 0.05). Conclusions: The study identifies distinct differences in the presence of amorphous masses and the expression levels of p53, Bcl-2, and CD31 between sun-exposed skin and in situ cutaneous squamous cell carcinomas, including actinic keratoses. |
Description: | Publisher Copyright: © 2023 by the authors. |
DOI: | 10.3390/jcm12237291 |
ISSN: | 2077-0383 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Expression_of_p53.pdf | 3 MB | Adobe PDF | View/Open |
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