Please use this identifier to cite or link to this item:
10.3390/jcm12237291
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Balcere, Alise | - |
dc.contributor.author | Sperga, Māris | - |
dc.contributor.author | Čēma, Ingrīda | - |
dc.contributor.author | Lauskis, Gunārs | - |
dc.contributor.author | Zolovs, Maksims | - |
dc.contributor.author | Rone-Kupfere, Māra | - |
dc.contributor.author | Krūmiņa, Angelika | - |
dc.date.accessioned | 2023-11-29T15:50:01Z | - |
dc.date.available | 2023-11-29T15:50:01Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.citation | Balcere , A , Sperga , M , Čēma , I , Lauskis , G , Zolovs , M , Rone-Kupfere , M & Krūmiņa , A 2023 , ' Expression of p53, p63, p16, Ki67, Cyclin D, Bcl-2, and CD31 Markers in Actinic Keratosis, In Situ Squamous Cell Carcinoma and Normal Sun-Exposed Skin of Elderly Patients ' , Journal of Clinical Medicine , vol. 12 , no. 23 , 7291 . https://doi.org/10.3390/jcm12237291 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/15016 | - |
dc.description | Publisher Copyright: © 2023 by the authors. | - |
dc.description.abstract | Background: Age and cumulative exposure to ultraviolet (UV) light are primary contributors to skin cancer development. Regulatory proteins within the cell cycle are essential for the homeostasis of squamous epithelium. Methods: This study assessed the expression of immunohistochemical markers p53, p63, p16, Ki67, Cyclin D, Bcl-2, and CD31 in keratinocyte intraepithelial neoplasia (actinic keratosis and squamous cell carcinoma in situ) compared to normal skin. The objective was to distinguish disease-specific changes from those attributable to ageing and sun exposure in elderly skin. Results. Analysis included 22 actinic keratoses (AK), 7 in situ squamous cell carcinomas (SCC), and 8 normal skin biopsies. The mean age was 78.1 years for the AK/SCC group and 73.8 years for controls, with no significant age difference noted between the groups. The AK/SCC group exhibited a higher occurrence of amorphous masses, higher intensity of p53, lower Bcl-2 expression in the epidermis, higher Bcl-2 expression in the dermis, and higher CD31 expression in the dermis, all of which were statistically significant (p < 0.05). Conclusions: The study identifies distinct differences in the presence of amorphous masses and the expression levels of p53, Bcl-2, and CD31 between sun-exposed skin and in situ cutaneous squamous cell carcinomas, including actinic keratoses. | en |
dc.format.extent | 11 | - |
dc.format.extent | 3074393 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Journal of Clinical Medicine | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | age | - |
dc.subject | UV damage | - |
dc.subject | immunohistochemistry | - |
dc.subject | cell cycle regulatory markers | - |
dc.subject | skin cancer | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 4.1 Agriculture, Forestry, and Fisheries | - |
dc.subject | 4.3 Veterinary science | - |
dc.subject | 1.6 Biological sciences | - |
dc.subject | 3.3 Health sciences | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Expression of p53, p63, p16, Ki67, Cyclin D, Bcl-2, and CD31 Markers in Actinic Keratosis, In Situ Squamous Cell Carcinoma and Normal Sun-Exposed Skin of Elderly Patients | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/jcm12237291 | - |
dc.contributor.institution | Department of Dermatology and Venereology | - |
dc.contributor.institution | Department of Oral and Maxillofacial Surgery and Oral Medicine | - |
dc.contributor.institution | Statistics Unit | - |
dc.contributor.institution | Department of Infectology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85179334918&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Expression_of_p53.pdf | 3 MB | Adobe PDF | View/Open |
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