Title: | Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Aura |
Authors: | Plinta, Aelita Tretjakovs, Pēteris Svirskis, Šimons Logina, Ināra Gersone, Gita Jurka, Antra Mikelsone, Indra Blumfelds, Leons Mackēvičs, Vitolds Bahs, Guntis Faculty of Medicine |
Keywords: | 3.1 Basic medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database |
Issue Date: | Oct-2022 |
Citation: | Plinta , A , Tretjakovs , P , Svirskis , Š , Logina , I , Gersone , G , Jurka , A , Mikelsone , I , Blumfelds , L , Mackēvičs , V & Bahs , G 2022 , ' Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Aura ' , Journal of Clinical Medicine , vol. 11 , no. 19 , 5696 , pp. 1-12 . |
Abstract: | The aim of the study was to clarify correlations between body mass index (BMI), blood pressure (BP), and serum levels of cytokines in female migraine patients. A total of 14 migraineurs with aura, and 12 without aura during their interictal period were compared with 25 controls. Interleukin-8 (IL-8), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), interferon gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor alpha (TGF-α), and plasminogen activator inhibitor-1 (PAI-1) were measured. Migraineurs have elevated levels of IL-8, but decreased serum levels of PAI-1 and sICAM-1 during the interictal period, regardless of aura. BMI correlates with BP, and also with IFN-γ and MMP-9 only in patients with aura. There are three correlations in migraine patients with aura that are absent in patients without aura: between IL-8 and PAI-1; MMP-9 and IL-8; and IL-8 and sICAM-1. Migraineurs without aura, on the other hand, have correlations that patients with aura do not have (between PAI-1 and MCP-1, sICAM-1; between MMP-9 and sICAM-1, MCP-1; between TGF-α and PAI-1, MMP-9, sICAM-1; between sICAM-1 and MMP-9, PAI-1, MCP-1; as well as between sVCAM-1 and MCP-1). PAI-1, TGF, and MMP-9 could be used as biomarkers to distinguish migraineurs from healthy individuals. |
Description: | Publisher Copyright: © 2022 by the authors. |
ISSN: | 2077-0383 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Description | Size | Format | |
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Association_of_Body_Mass_Index_Blood_Pressure_and_Interictal_Serum_Levels_of_Cytokines_in_Migraine_with_and_without_Aura.pdf | 32.14 MB | Adobe PDF | View/Open | |
Association_of_Body_Mass_Index_Blood_Pressure.pdf | 32.14 MB | Adobe PDF | View/Open |
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