Please use this identifier to cite or link to this item:
10.22038/IJORL.2021.53716.2842
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DC Field | Value | Language |
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dc.contributor.author | Dambergs, Kristaps | - |
dc.contributor.author | Sumeraga, Gunta | - |
dc.contributor.author | Pilmane, Māra | - |
dc.date.accessioned | 2022-08-16T21:02:39Z | - |
dc.date.available | 2022-08-16T21:02:39Z | - |
dc.date.issued | 2022-03 | - |
dc.identifier.citation | Dambergs , K , Sumeraga , G & Pilmane , M 2022 , ' Remodeling Factors, Transcription Factors and Angiogenetic Factors in Cholesteatoma in Ontogenetic Aspect ' , Iranian Journal of Otorhinolaryngology , vol. 34 , no. 2 , pp. 71-81 . https://doi.org/10.22038/IJORL.2021.53716.2842 | - |
dc.identifier.issn | 2251-7251 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/9386 | - |
dc.description | Publisher Copyright: © 2022 Mashhad University of Medical Sciences. All rights reserved. | - |
dc.description.abstract | Introduction: The main goal of our study was to describe the transcription factor (NF-κβ), angiogenetic factor (VEGF), and remodeling markers (MMP-9 and TIMP-4) of the cholesteatoma tissue compared to control skin tissue. There are still uncertainties how transcription, angiogenetic and remodeling factors affect the cholesteatoma course. Materials and Methods: Eight cholesteatoma tissue specimens were retrieved from children, seven – from adults, seven skin controls – from cadavers. Obtained material immunohistochemically were stained for NF-κβ, MMP-9, TIMP-4, VEGF. Non-parametric statistic methods were used. Results: A statistically significant higher numbers of NF-κβ and TIMP-4 immunoreactive cells in the cholesteatoma compared to control group. A very strong positive correlation between MMP-9 and TIMP-4 was seen in the patient group. A strong positive correlation - between MMP-9 in matrix and MMP-9, VEGF in perimatrix, between TIMP-4 in matrix and TIMP-4 in perimatrix, NF-κβ in the matrix and VEGF; between TIMP-4 in perimatrix and NF-κβ in the matrix. Conclusions: Correlation between MMP-9 and TIMP-4 suggests that TIMP-4 in cholesteatoma tissue intercorrelates to MMP9. TIMP-4 likely regulates the development of cholesteatoma. Disbalance between MMPs and TIMPs affects NFκβ and causes uncontrolled cell proliferation and immune response in this tumor. There is a lack of VEGF strong expression in cholesteatoma perimatrix. | en |
dc.format.extent | 11 | - |
dc.format.extent | 2322963 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Iranian Journal of Otorhinolaryngology | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Cholesteatoma | - |
dc.subject | Transcription factor | - |
dc.subject | Metalloproteases | - |
dc.subject | Vascular endothelial growth factor | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Otorhinolaryngology | - |
dc.title | Remodeling Factors, Transcription Factors and Angiogenetic Factors in Cholesteatoma in Ontogenetic Aspect | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.22038/IJORL.2021.53716.2842 | - |
dc.contributor.institution | Department of Otorhinolaryngology | - |
dc.contributor.institution | Institute of Anatomy and Anthropology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85129094668&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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IJORL_Volume_34_Issue_2_Pages_71_81.pdf | 2.27 MB | Adobe PDF | View/Open |
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