Please use this identifier to cite or link to this item:
10.3390/medicina48100077
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DC Field | Value | Language |
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dc.contributor.author | Rumaks, Juris | - |
dc.contributor.author | Pupure, Jolanta | - |
dc.contributor.author | Svirskis, Simons | - |
dc.contributor.author | Isajevs, Sergejs | - |
dc.contributor.author | Duburs, Gunars | - |
dc.contributor.author | Kalvinsh, Ivars | - |
dc.contributor.author | Klusa, Vija | - |
dc.date.accessioned | 2022-02-03T11:15:01Z | - |
dc.date.available | 2022-02-03T11:15:01Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Rumaks , J , Pupure , J , Svirskis , S , Isajevs , S , Duburs , G , Kalvinsh , I & Klusa , V 2012 , ' Search for stroke-protecting agents in endothelin-1-induced ischemic stroke model in rats ' , Medicina (Lithuania) , vol. 48 , no. 10 , pp. 525-531 . https://doi.org/10.3390/medicina48100077 | - |
dc.identifier.issn | 1010-660X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/7445 | - |
dc.description.abstract | Background and Objective. Ischemic stroke may initiate a reperfusion injury leadingto brain damage cascades where inflammatory mechanisms play a major role. Therefore, thenecessity for the novel stroke-protecting agents whose the mechanism of action is focused on their anti-inflammatory potency is still on the agenda for drug designers. Our previous studies demonstrated that cerebrocrast (a 1,4-dihydropyridine derivative) and mildronate (a representative of the aza-butyrobetaine class) possessed considerable anti-inflammatory and neuroprotective properties in different in vitro and in vivo model systems.The present study investigated their stroke-protecting ability in an endothelin-1 (ET-1)-induced ischemic stroke model in rats. Material and Methods. Male Wistar rats were pretreated (for 7 days, per os) with cerebrocrast (0.1 mg/kg), mildronate (100 mg/kg), or their combination, followed by the intracerebral injection of ET-1. Functional and behavioral tests were carried out up to 14 days after the ET-1 injection. Ex vivo, the number of degenerated neurons and the infarction size in the cerebral cortical tissue were assessed histologically. Results. Cerebrocrast and mildronate effectively normalized ET-1-induced disturbances in neurological status, improved the muscle tone, and decreased the number of degenerated cortical cells. Both drugs also reduced the infarction size, and cerebrocrast showed at least a 2-fold higher activity than mildronate. The combination of both drugs did not cause a more pronounced effect in comparison with the action of drugsadministered separately. Conclusions. The 1,4-dihydropyridine and aza-butyrobetaine structures may serve for the design of novel stroke-protecting agents to prevent severe neurological poststroke consequences. | en |
dc.format.extent | 7 | - |
dc.format.extent | 674175 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Medicina (Lithuania) | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Cerebrocrast | - |
dc.subject | Endothelin-1 | - |
dc.subject | Ischemic stroke | - |
dc.subject | Mildronate | - |
dc.subject | Neurodegeneration | - |
dc.subject | Protection | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General Medicine | - |
dc.title | Search for stroke-protecting agents in endothelin-1-induced ischemic stroke model in rats | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/medicina48100077 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84875550029&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Search_for_Stroke_Protecting_Agents_in_Endothelin_1_Induced_Ischemic_Stroke_Model_in_Rats.pdf | 658.37 kB | Adobe PDF | View/Open![]() |
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