Please use this identifier to cite or link to this item:
10.3390/M1311
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DC Field | Value | Language |
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dc.contributor.author | Rucins, Martins | - |
dc.contributor.author | Pajuste, Karlis | - |
dc.contributor.author | Plotniece, Aiva | - |
dc.contributor.author | Pikun, Nadiia | - |
dc.contributor.author | Rodik, Roman | - |
dc.contributor.author | Vyshnevskiy, Sergiy | - |
dc.contributor.author | Sobolev, Arkadij | - |
dc.date.accessioned | 2022-02-01T16:45:01Z | - |
dc.date.available | 2022-02-01T16:45:01Z | - |
dc.date.issued | 2022-03 | - |
dc.identifier.citation | Rucins , M , Pajuste , K , Plotniece , A , Pikun , N , Rodik , R , Vyshnevskiy , S & Sobolev , A 2022 , ' Synthesis and characterisation of 1,1'-{[3,5-bis(Dodecyloxy-carbonyl)-4-(thiophen-3-yl)-1,4-dihydropyridine-2,6-diyl]bis-(methylene)}bis(pyridin-1-ium) dibromide ' , MolBank , vol. 2022 , no. 1 , M1311 . https://doi.org/10.3390/M1311 | - |
dc.identifier.issn | 1422-8599 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/7404 | - |
dc.description | Funding Information: Funding: This research was funded by The Joint Ukraine-Latvia R&D Project “Design and study of physicochemical properties and bioactivity of self-assembling calixarene and dihydropyridine hybrids for DNA delivery”, grant number LV-UA/2020/3. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.description.abstract | In the present work, construction of double-charged cationic amphiphilic 1,1′-{[3,5-bis(dodecyl¬oxy-carbonyl)-4-(thiophen-3-yl)-1,4-dihydropyridine-2,6-diyl]bis-(methylene)}bis(pyridin-1-ium) dibromide (7) was performed in four steps. Dodecyl 3-oxobutanoate (1) was condensed with thiophene-3-carbaldehyde (2) which was necessary for Hantzsch cyclisation dodecyl (E/Z)-3-oxo-2-(thiophen-3-ylmethylene)butanoate (3). Two-component Hantzsch type cyclisation of dodecyl (E/Z)-3-aminobut-2-enoate (4) and dodecyl (E/Z)-3-oxo-2-(thiophen-3-ylmethylene)butanoate (3) gave 3,5-bis(dodecyloxycarbonyl)-2,6-dimethyl-4-(thiophen-3-yl)-1,4-dihydropyridine (5). Bromination of compound 5 followed by nucleophilic substitution of bromine with pyridine gave the desired cationic amphiphilic 1,4-dihydropyridine 7. The obtained target compound 7 and new intermediates 3, 5 and 6 were fully characterised by IR, UV,1 H NMR,13 C NMR, HRMS or microanalysis. Characterisation of nanoparticles formed by the cationic 1,4-dihydropyridine 7 in an aqueous solution was performed by DLS measurements. | en |
dc.format.extent | 401403 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | MolBank | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | 1,4-dihydropyridines | - |
dc.subject | DLS | - |
dc.subject | Nanoparticles | - |
dc.subject | Self-assembling properties | - |
dc.subject | Synthetic lipids | - |
dc.subject | 1.4 Chemical sciences | - |
dc.subject | 1.6 Biological sciences | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Biochemistry | - |
dc.subject | Physical and Theoretical Chemistry | - |
dc.subject | Organic Chemistry | - |
dc.title | Synthesis and characterisation of 1,1'-{[3,5-bis(Dodecyloxy-carbonyl)-4-(thiophen-3-yl)-1,4-dihydropyridine-2,6-diyl]bis-(methylene)}bis(pyridin-1-ium) dibromide | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/M1311 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85121780495&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Synthesis_and_Characterisation.pdf | 392 kB | Adobe PDF | View/Open |
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