Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Sabeļņikovs, Oļegs | - |
dc.contributor.author | Ņikitina-Zaķe, Liene | - |
dc.contributor.author | Krūmiņa, Angelika | - |
dc.contributor.author | Jaunberga, Zane | - |
dc.contributor.author | Klovins, Jānis | - |
dc.contributor.author | Vīksna, Ludmila | - |
dc.contributor.author | Bjertnaes, Lars J. | - |
dc.contributor.author | Kovalchuka, Lilija | - |
dc.contributor.author | Vanags, Indulis | - |
dc.date.accessioned | 2022-01-27T17:00:01Z | - |
dc.date.available | 2022-01-27T17:00:01Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Sabeļņikovs , O , Ņikitina-Zaķe , L , Krūmiņa , A , Jaunberga , Z , Klovins , J , Vīksna , L , Bjertnaes , L J , Kovalchuka , L & Vanags , I 2012 , ' Associations between TNF-α, IL-6 and IL-10 Promoter Polymorphisms and Mortality in Severe Sepsis ' , Journal of Scientific Research and Reports , vol. 1 , no. 1 , JSRR.2012.002 , pp. 17-28 . | - |
dc.identifier.issn | 2320-0227 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/7337 | - |
dc.description.abstract | Aims: To determine whether an association exists between TNF-α308 A/G,IL-6174G/C, and IL-10-1082 A/G promoter polymorphisms and the corresponding systemic cytokine concentrations and outcome in patients suffering from sepsis. Place and Duration of Study: The study was performed in the Intensive Care Unit (ICU) of Pauls Stradins Clinical University Hospital, Riga. Between 1 August 2006 and 31 July2008. Methodology: We enrolled 103 consecutive intensive care unit patients with sepsis into a prospective case control study. Blood samples were obtained for extraction of DNA amplifying regions of interest by means of polymerase chain reaction technique (PCR)using specific primers for TNF-α, IL-6andIL-10. Simultaneously, plasma cytokines and standard laboratory variables were determined during the first 24 h after the diagnosis. Presence of septic shock, sequential organ failure assessment score (SOFA),demographic data and clinical outcome was noticed P < 0.05 was considered as statistically significant. Results: Non-survivors had significantly higher concentrations of TNF-α, IL-6 and IL-10.The carriage of the IL-6-174C allele and IL-10-1082G allele were associated with a higher risk of mortality in patients with severe sepsis. Presence of the TNF-α-308 A allele did not influence mortality differently from those lacking this allele. Conclusion: The present study demonstrated an association of the IL-6-174 and the IL-10-1082 with increased mortality in patients suffering from severe sepsis. We found no direct association between the examined polymorphisms and the corresponding cytokine levels. | en |
dc.format.extent | 235522 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Journal of Scientific Research and Reports | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Sepsis | - |
dc.subject | TNF-α | - |
dc.subject | IL-6 | - |
dc.subject | IL-10 | - |
dc.subject | polymorphisms, allele | - |
dc.subject | PCR | - |
dc.subject | SNP | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions) | - |
dc.title | Associations between TNF-α, IL-6 and IL-10 Promoter Polymorphisms and Mortality in Severe Sepsis | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.contributor.institution | Department of Anaesthesiology and Intensive Care | - |
dc.contributor.institution | Department of Infectology | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Association_between_TNF_alpha_IL_6_and_IL_10.pdf | 230 kB | Adobe PDF | View/Open |
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