Please use this identifier to cite or link to this item:
10.3390/medicina57010078
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DC Field | Value | Language |
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dc.contributor.author | Hofmanis, Juris | - |
dc.contributor.author | Tretjakovs, Peteris | - |
dc.contributor.author | Svirskis, Simons | - |
dc.contributor.author | Gersone, Gita | - |
dc.contributor.author | Hofmane, Dace | - |
dc.contributor.author | Rozenberga, Ulla | - |
dc.contributor.author | Blumfelds, Leons | - |
dc.contributor.author | Bahs, Guntis | - |
dc.contributor.author | Lejnieks, Aivars | - |
dc.contributor.author | Mackevics, Vitolds | - |
dc.date.accessioned | 2022-01-24T22:01:08Z | - |
dc.date.available | 2022-01-24T22:01:08Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.citation | Hofmanis , J , Tretjakovs , P , Svirskis , S , Gersone , G , Hofmane , D , Rozenberga , U , Blumfelds , L , Bahs , G , Lejnieks , A & Mackevics , V 2021 , ' Prognostic utility of circulating growth factors in aortic valve stenosis : A pilot study ' , Medicina (Lithuania) , vol. 57 , no. 1 , 78 , pp. 1-13 . https://doi.org/10.3390/medicina57010078 | - |
dc.identifier.issn | 1010-660X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/7266 | - |
dc.description | Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved. | - |
dc.description.abstract | Background and Objectives: Aortic valve stenosis (AS) develops with a pronounced local inflammatory response, where a variety of growth factors are involved in the process, and may have a pro-inflammatory and anti-inflammatory effect. The aim of our study was to elucidate whether circulating growth factors: growth differentiation factor 15 (GDF-15), angiopoietin-2 (Ang-2), vascular endothelial growth factor A (VEGF-A), fibroblast growth factor 2 (FGF-2), and fibroblast growth factor 21 (FGF-21) could be proposed as clinically relevant biomarkers to improve risk stratification in AS patients. Materials and Methods: AS patients were classified into three groups: 16 patients with mild AS stenosis; 19 with moderate and 11 with severe AS, and 30 subjects without AS (echocardiographically approved) were selected as a control group. GDF-15, Ang-2, VEGF-A, FGF-2, and FGF-21 were measured in plasma by the ELISA method. Results: GDF-15 levels differed significantly not only when comparing AS patients with control groups (p < 0.0001), but also a statistically significant difference was achieved when comparing AS patients at a mild degree stage with control individuals. We found a strong relationship of GDF-15 levels regarding AS severity degree (p < 0.0001). VEGF-A, FGF-2 and FGF-21 levels were significantly higher in AS patients than in controls, but relationships regarding the AS severity degree were weaker (p < 0.02). ROC analysis of the study growth factors showed that GDF-15 might serve as a specific and sensitive biomarker of AS stenosis (AUC = 0.75, p = 0.0002). FGF-21 correlated with GDF-15, Ang-2, and FGF-2, but it did not reach the level to serve as a clinically relevant biomarker of AS stenosis. Conclusions: AS is associated with significantly increased GDF-15, VEGF-A, FGF-2, and FGF-21 levels in plasma, but only GDF-15 shows a pronounced relationship regarding AS severity degree, and GDF-15 might serve as a specific and sensitive biomarker of AS stenosis. | en |
dc.format.extent | 5266069 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Medicina (Lithuania) | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Angiopoietin-2 | - |
dc.subject | Aortic valve stenosis | - |
dc.subject | Fibroblast growth factor 2 | - |
dc.subject | Fibroblast growth factor-21 | - |
dc.subject | Growth differentiation factor 15 | - |
dc.subject | Vascular endothelial growth factor A | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General Medicine | - |
dc.title | Prognostic utility of circulating growth factors in aortic valve stenosis : A pilot study | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/medicina57010078 | - |
dc.contributor.institution | Faculty of Medicine | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85099558817&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Prognostic_Utility_of_Circulating_Growth_Factors.pdf | 5.14 MB | Adobe PDF | View/Open |
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