Please use this identifier to cite or link to this item:
10.33678/COR.2021.046
Title: | Oxidative stress, depression, and risk of recurrence of stable coronary heart disease |
Authors: | Ivascenko, Tarass Voicehovskis, Vladimirs V. Voicehovska, Julija G. Skesters, Andrejs Apsite, Ketija Grigorjeva, Julija Kivite-Urtane, Anda Pahomova, Natalija Kalejs, Oskars Rīga Stradiņš University |
Keywords: | Depression;Geriatric depression scale;GPx;MDA;Oxidative stress;Stable coronary heart disease;5.1 Psychology;3.3 Health sciences;3.1 Basic medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Cardiology and Cardiovascular Medicine |
Issue Date: | 2021 |
Citation: | Ivascenko , T , Voicehovskis , V V , Voicehovska , J G , Skesters , A , Apsite , K , Grigorjeva , J , Kivite-Urtane , A , Pahomova , N & Kalejs , O 2021 , ' Oxidative stress, depression, and risk of recurrence of stable coronary heart disease ' , Cor et Vasa , vol. 63 , no. 5 , pp. 555-563 . https://doi.org/10.33678/COR.2021.046 |
Abstract: | Aim: The aim of the study was to investigate the relationships between a level of oxidative stress (OS), depression (D) and risk of recurrence of stable coronary heart disease (SCHD). Methods: A retrospective study was conducted on 174 participants, at the age 45+ years: 86 in-patients of the cardiology department with a recurrent SCHD and 88 in-patients of the cardiology department with primary SCHD. The severity of depressive symptoms was assessed using the long 30-item form of Geriatric Depression Scale (GDS), valid Latvian version of GDS-LAT. The blood samples were taken from each patient to measure oxidative stress parameters malondialdehyde (MDA) and glutathione peroxidase (GPx). Results: 83.9% of the sample had high level of MDA. In 72.4% of the sample the GPx level was normal, in 17.8% it was high and in 9.8% low. Slightly more than a half of the patients were experiencing depression (44.3% – mild D and 6.9% – severe D). GPx was found statistically differing between primary and recurrent SCHD (p = 0,003). Patients with both D and high GPx had 10.6 times higher chances of recurrent SHCD compared to those without D and normal GPx (p = patients with present D were experiencing both – high levels of MDA and GPx – more often than responders with no D, but this wasn’t statistically significant [p = 0.51]). Conclusion: In the present study it was found that level of antioxidant (AO) enzyme GPx was significantly higher in depressed patients with recurrent SCHD compared to patients without D and to patients with primary SCHD and patients with both D and high GPx had higher chances of recurrent SCHD compared to those without D and normal GPx. It could be supposed that GPx is a more significant marker of risk of D and recurrence of SCHD. The high level of MDA in most of both (primary and recurrent SCHD) groups patients could evidence that increased OS is a risk factor for CHD in general. Monitoring OS biomarkers seems to be important in the management of SCHD comorbidity with D. Further studies are warranted to confirm these findings. |
Description: | Funding Information: Research project was supported by RSU PhD grant. Publisher Copyright: © 2021, ČKS. |
DOI: | 10.33678/COR.2021.046 |
ISSN: | 0010-8650 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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