Please use this identifier to cite or link to this item:
10.1111/j.1365-2036.2007.03468.x
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Eliakim, R. | - |
dc.contributor.author | Tulassay, Z. | - |
dc.contributor.author | Kupcinskas, L. | - |
dc.contributor.author | Adamonis, K. | - |
dc.contributor.author | Pokrotnieks, J. | - |
dc.contributor.author | Bar-Meir, S. | - |
dc.contributor.author | Lavy, A. | - |
dc.contributor.author | Mueller, R. | - |
dc.contributor.author | Greinwald, R. | - |
dc.contributor.author | Chermesh, I. | - |
dc.contributor.author | Gross, V. | - |
dc.date.accessioned | 2021-12-14T09:40:01Z | - |
dc.date.available | 2021-12-14T09:40:01Z | - |
dc.date.issued | 2007-11 | - |
dc.identifier.citation | Eliakim , R , Tulassay , Z , Kupcinskas , L , Adamonis , K , Pokrotnieks , J , Bar-Meir , S , Lavy , A , Mueller , R , Greinwald , R , Chermesh , I & Gross , V 2007 , ' Clinical trial : Randomized-controlled clinical study comparing the efficacy and safety of a low-volume vs. a high-volume mesalazine foam in active distal ulcerative colitis ' , Alimentary Pharmacology and Therapeutics , vol. 26 , no. 9 , pp. 1237-1249 . https://doi.org/10.1111/j.1365-2036.2007.03468.x | - |
dc.identifier.issn | 0269-2813 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/7044 | - |
dc.description | Members of the International Salofalk Foam Study Group are listed in the Appendix of this article. Members from Latvia are: J.Derova, J.Trofimovica, J.Pokrotnieks, A.Danilans, A.Pukitis, I.Tolmanis, M.Leja, I.Poikane, A.Sudraba. | - |
dc.description.abstract | Background: Rectally administered mesalazine (mesalamine; 5-aminosalicylic acid) is the first-line therapy for treatment of distal ulcerative colitis. Recently, a high-volume 5-aminosalicylic acid foam has been shown to be as effective and safe as standard 5-aminosalicylic acid enema. Aim: To study the efficacy and safety of a low-volume vs. a high-volume 5-aminosalicylic acid foam. Methods: In this investigator-blinded study, patients with active distal ulcerative colitis [Clinical Activity Index (CAI) > 4, Endoscopic Index ≥ 4] were randomized to receive 2 × 1 g/30 mL low-volume (n = 163) or 2 × 1 g/60 mL high-volume 5-aminosalicylic acid foam (n = 167) for 42 days. Primary end point was clinical remission (CAI ≤ 4) at the final/withdrawal visit (per-protocol). Results: 330 patients were evaluable for efficacy and safety by intention-to-treat, 290 for per-protocol analysis. Clinical remission rates at week 6 (per-protocol) were 77% on low-volume foam vs. 77% on high-volume foam (P = 0.00002 for non-inferiority). The low-volume foam was associated with a lower frequency of severe discomfort, pain and retention problems. Conclusions: Low-volume 5-aminosalicylic acid foam is as effective and safe as a high-volume 5-aminosalicylic acid foam in the treatment of active distal ulcerative colitis, but offers compliance advantages compared to the high-volume preparation. | en |
dc.format.extent | 13 | - |
dc.format.extent | 213335 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Alimentary Pharmacology and Therapeutics | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Hepatology | - |
dc.subject | Gastroenterology | - |
dc.subject | Pharmacology (medical) | - |
dc.title | Clinical trial : Randomized-controlled clinical study comparing the efficacy and safety of a low-volume vs. a high-volume mesalazine foam in active distal ulcerative colitis | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1111/j.1365-2036.2007.03468.x | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=35449008088&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
---|---|---|---|
Clinical_trial.pdf | 208.33 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.