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10.1007/s10549-018-4825-8
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DC Field | Value | Language |
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dc.contributor.author | O’Loughlin, Mark | - |
dc.contributor.author | Andreu, Xavier | - |
dc.contributor.author | Bianchi, Simonetta | - |
dc.contributor.author | Chemielik, Ewa | - |
dc.contributor.author | Cordoba, Alicia | - |
dc.contributor.author | Cserni, Gábor | - |
dc.contributor.author | Figueiredo, Paulo | - |
dc.contributor.author | Floris, Giuseppe | - |
dc.contributor.author | Foschini, Maria P. | - |
dc.contributor.author | Heikkilä, Päivi | - |
dc.contributor.author | Kulka, Janina | - |
dc.contributor.author | Liepniece-Karele, Inta | - |
dc.contributor.author | Regitnig, Peter | - |
dc.contributor.author | Reiner, Angelika | - |
dc.contributor.author | Ryska, Ales | - |
dc.contributor.author | Sapino, Anna | - |
dc.contributor.author | Shalaby, Aliaa | - |
dc.contributor.author | Stovgaard, Elisabeth Specht | - |
dc.contributor.author | Quinn, Cecily | - |
dc.contributor.author | Walsh, Elaine M. | - |
dc.contributor.author | Zolota, Vicky | - |
dc.contributor.author | Glynn, Sharon A. | - |
dc.contributor.author | Callagy, Grace | - |
dc.date.accessioned | 2021-12-13T09:25:01Z | - |
dc.date.available | 2021-12-13T09:25:01Z | - |
dc.date.issued | 2018-08-01 | - |
dc.identifier.citation | O’Loughlin , M , Andreu , X , Bianchi , S , Chemielik , E , Cordoba , A , Cserni , G , Figueiredo , P , Floris , G , Foschini , M P , Heikkilä , P , Kulka , J , Liepniece-Karele , I , Regitnig , P , Reiner , A , Ryska , A , Sapino , A , Shalaby , A , Stovgaard , E S , Quinn , C , Walsh , E M , Zolota , V , Glynn , S A & Callagy , G 2018 , ' Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer : a multi-institutional study ' , Breast Cancer Research and Treatment , vol. 171 , no. 1 , pp. 1-9 . https://doi.org/10.1007/s10549-018-4825-8 | - |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/7031 | - |
dc.description | Funding Information: Funding This work was funded by Breast Cancer Now (2013MayPR019 and 2015NovPhD643), Science Foundation Ireland (17/CDA/4638) and Irish Cancer Society (SG); Breast Cancer Research (EW), and an NUI Galway School of Medicine Scholarship (EW). Publisher Copyright: © 2018, The Author(s). | - |
dc.description.abstract | Background: Several studies have demonstrated a prognostic role for stromal tumour infiltrating lymphocytes (sTILs) in triple-negative breast cancer (TNBC). The reproducibility of scoring sTILs is variable with potentially excellent concordance being achievable using a software tool. We examined agreement between breast pathologists across Europe scoring sTILs on H&E-stained sections without software, an approach that is easily applied in clinical practice. The association between sTILs and response to anthracycline-taxane NACT was also examined. Methodology: Pathologists from the European Working Group for Breast Screening Pathology scored sTILs in 84 slides from 75 TNBCs using the immune-oncology biomarker working group guidance in two circulations. There were 16 participants in the first and 19 in the second circulation. Results: Moderate agreement was achieved for absolute sTILs scores (intraclass correlation coefficient (ICC) = 0.683, 95% CI 0.601–0.767, p-value < 0.001). Agreement was less when a 25% threshold was used (ICC 0.509, 95% CI 0.416–0.614, p-value < 0.001) and for lymphocyte predominant breast cancer (LPBC) (ICC 0.504, 95% CI 0.412–0.610, p-value < 0.001). Intra-observer agreement was strong for absolute sTIL values (Spearman ρ = 0.727); fair for sTILs ≥ 25% (κ = 0.53) and for LPBC (κ = 0.49), but poor for sTILs as 10% increments (κ = 0.24). Increasing sTILs was significantly associated with an increased likelihood of a pathological complete response (pCR) on multivariable analysis. Conclusion: Increasing sTILs in TNBCs improves the likelihood of a pCR. However, inter-observer agreement is such that H&E-based assessment is not sufficiently reproducible for clinical application. Other methodologies should be explored, but may be at the cost of ease of application. | en |
dc.format.extent | 9 | - |
dc.format.extent | 2011343 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Breast Cancer Research and Treatment | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Inter-observer agreement | - |
dc.subject | Neoadjuvant chemotherapy | - |
dc.subject | Pathological complete response | - |
dc.subject | sTILs | - |
dc.subject | Stromal tumour infiltrating lymphocytes | - |
dc.subject | Triple-negative breast cancer | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Oncology | - |
dc.subject | Cancer Research | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer : a multi-institutional study | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/editorial | - |
dc.identifier.doi | 10.1007/s10549-018-4825-8 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85047135321&partnerID=8YFLogxK | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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File | Size | Format | |
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Reproducibility_and_predictive_value_of_scoring_stromal_tumour.pdf | 1.96 MB | Adobe PDF | View/Open![]() |
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