Please use this identifier to cite or link to this item:
10.3390/nano11030593
Title: | Evaluation of physicochemical properties of amphiphilic 1,4-dihydropyridines and preparation of magnetoliposomes |
Authors: | Petrichenko, Oksana Plotniece, Aiva Pajuste, Karlis Rucins, Martins Dimitrijevs, Pavels Sobolev, Arkadij Sprugis, Einars Cēbers, Andrejs Department of Pharmaceutical Chemistry |
Keywords: | 1,4-dihydropyridine amphiphiles;Iron oxide nanoparticles;Lipid monolayers;Magnetoliposomes;Physicochemical properties;1.4 Chemical sciences;2.4 Chemical engineering;2.5 Materials engineering;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Chemical Engineering;General Materials Science |
Issue Date: | Mar-2021 |
Citation: | Petrichenko , O , Plotniece , A , Pajuste , K , Rucins , M , Dimitrijevs , P , Sobolev , A , Sprugis , E & Cēbers , A 2021 , ' Evaluation of physicochemical properties of amphiphilic 1,4-dihydropyridines and preparation of magnetoliposomes ' , Nanomaterials , vol. 11 , no. 3 , 593 . https://doi.org/10.3390/nano11030593 |
Abstract: | This study was focused on the estimation of the targeted modification of 1,4-DHP core with (1) different alkyl chain lengths at 3,5-ester moieties of 1,4-DHP (C12, C14 and C16 ); (2) N-substituent at position 1 of 1,4-DHP (N-H or N-CH3 ); (3) substituents of pyridinium moieties at positions 2 and 6 of 1,4-DHP (H, 4-CN and 3-Ph); (4) substituent at position 4 of 1,4-DHP (phenyl and napthyl) on physicochemical properties of the entire molecules and on the characteristics of the obtained magnetoliposomes formed by them. It was shown that thermal behavior of the tested 1,4-DHP amphiphiles was related to the alkyl chains length, the elongation of which decreased their transition temperatures. The properties of 1,4-DHP amphiphile monolayers and their polar head areas were determined. The packing parameters of amphiphiles were in the 0.43–0.55 range. It was demonstrated that the structure of 1,4-DHPs affected the physicochemical properties of compounds. “Empty” liposomes and magnetoliposomes were prepared from selected 1,4-DHP amphiphiles. It was shown that the variation of alkyl chains length or the change of substituents at positions 4 of 1,4-DHP did not show a significant influence on properties of liposomes. |
Description: | Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
DOI: | 10.3390/nano11030593 |
ISSN: | 2079-4991 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Evaluation_of_Physicochemical_Properties.pdf | 2.52 MB | Adobe PDF | View/Open![]() |
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