Evaluation of physicochemical properties of amphiphilic 1,4-dihydropyridines and preparation of magnetoliposomes

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dc.contributor.authorPetrichenko, Oksana
dc.contributor.authorPlotniece, Aiva
dc.contributor.authorPajuste, Karlis
dc.contributor.authorRucins, Martins
dc.contributor.authorDimitrijevs, Pavels
dc.contributor.authorSobolev, Arkadij
dc.contributor.authorSprugis, Einars
dc.contributor.authorCēbers, Andrejs
dc.contributor.institutionDepartment of Pharmaceutical Chemistry
dc.date.accessioned2021-12-06T22:01:45Z
dc.date.available2021-12-06T22:01:45Z
dc.date.issued2021-03
dc.descriptionPublisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractThis study was focused on the estimation of the targeted modification of 1,4-DHP core with (1) different alkyl chain lengths at 3,5-ester moieties of 1,4-DHP (C12, C14 and C16 ); (2) N-substituent at position 1 of 1,4-DHP (N-H or N-CH3 ); (3) substituents of pyridinium moieties at positions 2 and 6 of 1,4-DHP (H, 4-CN and 3-Ph); (4) substituent at position 4 of 1,4-DHP (phenyl and napthyl) on physicochemical properties of the entire molecules and on the characteristics of the obtained magnetoliposomes formed by them. It was shown that thermal behavior of the tested 1,4-DHP amphiphiles was related to the alkyl chains length, the elongation of which decreased their transition temperatures. The properties of 1,4-DHP amphiphile monolayers and their polar head areas were determined. The packing parameters of amphiphiles were in the 0.43–0.55 range. It was demonstrated that the structure of 1,4-DHPs affected the physicochemical properties of compounds. “Empty” liposomes and magnetoliposomes were prepared from selected 1,4-DHP amphiphiles. It was shown that the variation of alkyl chains length or the change of substituents at positions 4 of 1,4-DHP did not show a significant influence on properties of liposomes.en
dc.description.statusPeer reviewed
dc.format.extent17
dc.format.extent2579675
dc.identifier.citationPetrichenko, O, Plotniece, A, Pajuste, K, Rucins, M, Dimitrijevs, P, Sobolev, A, Sprugis, E & Cēbers, A 2021, 'Evaluation of physicochemical properties of amphiphilic 1,4-dihydropyridines and preparation of magnetoliposomes', Nanomaterials , vol. 11, no. 3, 593. https://doi.org/10.3390/nano11030593
dc.identifier.doi10.3390/nano11030593
dc.identifier.issn2079-4991
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6968
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85101669325&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofNanomaterials
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject1,4-dihydropyridine amphiphiles
dc.subjectIron oxide nanoparticles
dc.subjectLipid monolayers
dc.subjectMagnetoliposomes
dc.subjectPhysicochemical properties
dc.subject1.4 Chemical sciences
dc.subject2.4 Chemical engineering
dc.subject2.5 Materials engineering
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Chemical Engineering
dc.subjectGeneral Materials Science
dc.titleEvaluation of physicochemical properties of amphiphilic 1,4-dihydropyridines and preparation of magnetoliposomesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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