Please use this identifier to cite or link to this item:
10.3389/fped.2021.752385
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DC Field | Value | Language |
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dc.contributor.author | Roge, Ieva | - |
dc.contributor.author | Smane, Liene | - |
dc.contributor.author | Ķīvīte-Urtāne, Anda | - |
dc.contributor.author | Pucuka, Zanda | - |
dc.contributor.author | Racko, Iveta | - |
dc.contributor.author | Klavina, Lizete | - |
dc.contributor.author | Pavare, Jana | - |
dc.date.accessioned | 2021-11-23T18:55:01Z | - |
dc.date.available | 2021-11-23T18:55:01Z | - |
dc.date.issued | 2021-10-29 | - |
dc.identifier.citation | Roge , I , Smane , L , Ķīvīte-Urtāne , A , Pucuka , Z , Racko , I , Klavina , L & Pavare , J 2021 , ' Comparison of Persistent Symptoms After COVID-19 and Other Non-SARS-CoV-2 Infections in Children ' , Frontiers in Pediatrics , vol. 9 , 752385 . https://doi.org/10.3389/fped.2021.752385 | - |
dc.identifier.issn | 2296-2360 | - |
dc.identifier.other | PubMedCentral: PMC8586002 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/6871 | - |
dc.description | Funding Information: This study was supported by the State Research Program for the Mitigation of Consequences of COVID-19, project Nr.VPP-COVID-2020/1-011: Impact of COVID-19 on the healthcare system and public health in Latvia; ways to prepare the health sector for future epidemics, funded by the Latvian Council of Science. Publisher Copyright: Copyright © 2021 Roge, Smane, Kivite-Urtane, Pucuka, Racko, Klavina and Pavare. | - |
dc.description.abstract | Introduction: The data on long COVID in children is scarce since children and adolescents are typically less severely affected by acute COVID-19. This study aimed to identify the long-term consequences of SARS-CoV-2 infection in children, and to compare the persistent symptom spectrum between COVID-19 and community-acquired infections of other etiologies. Methods: This was an ambidirectional cohort study conducted at the Children's Clinical University Hospital in Latvia. The study population of pediatric COVID-19 patients and children with other non-SARS-CoV-2-community-acquired infections were invited to participate between July 1, 2020, and April 30, 2021. Results: In total, 236 pediatric COVID-19 patients were enrolled in the study. Additionally, 142 comparison group patients were also enrolled. Median follow-up time from acute symptom onset was 73.5 days (IQR; 43–110 days) in the COVID-19 patient group and 69 days (IQR, 58–84 days) in the comparison group. Most pediatric COVID-19 survivors (70%, N = 152) reported at least one persistent symptom, but more than half of the patients (53%, N = 117) noted two or more long-lasting symptoms. The most commonly reported complaints among COVID-19 patients included persistent fatigue (25.2%), cognitive sequelae, such as irritability (24.3%), and mood changes (23.3%), as well as headaches (16.9%), rhinorrhea (16.1%), coughing (14.4%), and anosmia/dysgeusia (12.3%). In addition, 105 (44.5%) COVID patients had persistent symptoms after the 12-week cut-off point, with irritability (27.6%, N = 29), mood changes (26.7%, N = 28), and fatigue (19.2%, N = 20) being the most commonly reported ones. Differences in symptom spectrum among the various age groups were seen. Logistic regression analysis showed that long-term persistent symptoms as fever, fatigue, rhinorrhea, loss of taste and/or smell, headaches, cognitive sequelae, and nocturnal sweating were significantly associated with the COVID-19 experience when compared with the controls. Conclusions: We found that at the time of interview almost three-quarters of children reported at least one persistent symptom, but the majority of patients (53%) had two or more concurrent symptoms. The comparison group's inclusion in the study allowed us to identify that symptom persistence is more apparent with COVID-19 than any other non-SARS-CoV-2 infection. More research is needed to distinguish the symptoms of long COVID from pandemic-associated complaints. Each persistent symptom is important in terms of child well-being during COVID-19 recovery. | en |
dc.format.extent | 13 | - |
dc.format.extent | 439459 | - |
dc.format.extent | 439459 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Frontiers in Pediatrics | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | clinical sequelae | - |
dc.subject | COVID-19 | - |
dc.subject | pediatrics | - |
dc.subject | SARS-CoV-2 | - |
dc.subject | viral | - |
dc.subject | 3.3 Health sciences | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Pediatrics, Perinatology, and Child Health | - |
dc.title | Comparison of Persistent Symptoms After COVID-19 and Other Non-SARS-CoV-2 Infections in Children | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3389/fped.2021.752385 | - |
dc.contributor.institution | Rīga Stradiņš University | - |
dc.contributor.institution | Institute of Public Health | - |
dc.contributor.institution | Department of Public Health and Epidemiology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85119050194&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Description | Size | Format | |
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fped_09_752385.pdf | 429.16 kB | Adobe PDF | View/Open | |
Comparison_of_Persistent_Symptoms_After_COVID_19_and_Other.pdf | 429.16 kB | Adobe PDF | View/Open |
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