Please use this identifier to cite or link to this item:
10.1111/j.1365-2036.2006.02743.x
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DC Field | Value | Language |
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dc.contributor.author | Gross, V. | - |
dc.contributor.author | Bar-Meir, S. | - |
dc.contributor.author | Lavy, A. | - |
dc.contributor.author | Mickisch, O. | - |
dc.contributor.author | Tulassay, Z. | - |
dc.contributor.author | Pronai, L. | - |
dc.contributor.author | Kupcinskas, L. | - |
dc.contributor.author | Kiudelis, G. | - |
dc.contributor.author | Pokrotnieks, J. | - |
dc.contributor.author | Kovács, Á | - |
dc.contributor.author | Faszczyk, M. | - |
dc.contributor.author | Razbadauskas, A. | - |
dc.contributor.author | Margus, B. | - |
dc.contributor.author | Stolte, M. | - |
dc.contributor.author | Müller, R. | - |
dc.contributor.author | Greinwald, R. | - |
dc.date.accessioned | 2021-11-15T14:45:01Z | - |
dc.date.available | 2021-11-15T14:45:01Z | - |
dc.date.issued | 2006-01 | - |
dc.identifier.citation | Gross , V , Bar-Meir , S , Lavy , A , Mickisch , O , Tulassay , Z , Pronai , L , Kupcinskas , L , Kiudelis , G , Pokrotnieks , J , Kovács , Á , Faszczyk , M , Razbadauskas , A , Margus , B , Stolte , M , Müller , R & Greinwald , R 2006 , ' Budesonide foam versus budesonide enema in active ulcerative proctitis and proctosigmoiditis ' , Alimentary Pharmacology and Therapeutics , vol. 23 , no. 2 , pp. 303-312 . https://doi.org/10.1111/j.1365-2036.2006.02743.x | - |
dc.identifier.issn | 0269-2813 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/6829 | - |
dc.description.abstract | Background: Rectal budesonide is an effective treatment of active ulcerative proctitis or proctosigmoiditis. Aim: To compare the therapeutic efficacy, tolerability and safety, and patient's preference of budesonide foam vs. budesonide enema. Methods: Patients with active ulcerative proctitis or proctosigmoiditis (clinical activity index >4 and endoscopic index ≥4) were eligible for this double-blind, double-dummy, randomized, multicentre study. They received 2 mg/25 mL budesonide foam and placebo enema (n = 265), or 2 mg/100 mL budesonide enema and placebo foam (n = 268) for 4 weeks. Primary endpoint was clinical remission (clinical activity index ≤4) at the final/withdrawal visit (per protocol). Results: A total of 541 patients were randomized - 533 were evaluable for intention-to-treat analysis and 449 for per protocol analysis. Clinical remission rates (per protocol) were 60% for budesonide foam and 66% for budesonide enema (P = 0.02362 for non-inferiority of foam vs. enema within a predefined non-inferiority margin of 15%). Both formulations were safe and no drug-related serious adverse events were observed. Because of better tolerability and easier application most patients preferred foam (84%). Conclusion: Budesonide foam is as effective as budesonide enema in the treatment of active ulcerative proctitis or proctosigmoiditis. Both budesonide formulations are safe, and most patients prefer foam. | en |
dc.format.extent | 10 | - |
dc.format.extent | 142554 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Alimentary Pharmacology and Therapeutics | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Hepatology | - |
dc.subject | Gastroenterology | - |
dc.subject | Pharmacology (medical) | - |
dc.title | Budesonide foam versus budesonide enema in active ulcerative proctitis and proctosigmoiditis | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1111/j.1365-2036.2006.02743.x | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=33644907461&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Budesonide_foam_versus_budesonide_enema.pdf | 139.21 kB | Adobe PDF | View/Open |
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