Please use this identifier to cite or link to this item:
10.1002/jcb.21224
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Morris, Russell A. | - |
dc.contributor.author | Damon, Brook | - |
dc.contributor.author | Mironov, Vladimir | - |
dc.contributor.author | Kasyanov, Vladimir | - |
dc.contributor.author | Ramamurthi, Anand | - |
dc.contributor.author | Moreno-Rodriguez, Ricardo | - |
dc.contributor.author | Trusk, Thomas | - |
dc.contributor.author | Potts, Jay D. | - |
dc.contributor.author | Goodwin, Richard L. | - |
dc.contributor.author | Davis, Jeff | - |
dc.contributor.author | Hoffman, Stanley | - |
dc.contributor.author | Wen, Xuejun | - |
dc.contributor.author | Sugi, Yukiko | - |
dc.contributor.author | Kern, Christine B. | - |
dc.contributor.author | Mjaatvedt, Corey H. | - |
dc.contributor.author | Turner, Debi K. | - |
dc.contributor.author | Oka, Toru | - |
dc.contributor.author | Conway, Simon J. | - |
dc.contributor.author | Molkentin, Jeffery D. | - |
dc.contributor.author | Forgacs, Gabor | - |
dc.contributor.author | Markwald, Roger R. | - |
dc.date.accessioned | 2021-10-31T19:00:01Z | - |
dc.date.available | 2021-10-31T19:00:01Z | - |
dc.date.issued | 2007-06-01 | - |
dc.identifier.citation | Morris , R A , Damon , B , Mironov , V , Kasyanov , V , Ramamurthi , A , Moreno-Rodriguez , R , Trusk , T , Potts , J D , Goodwin , R L , Davis , J , Hoffman , S , Wen , X , Sugi , Y , Kern , C B , Mjaatvedt , C H , Turner , D K , Oka , T , Conway , S J , Molkentin , J D , Forgacs , G & Markwald , R R 2007 , ' Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues ' , Journal of Cellular Biochemistry , vol. 101 , no. 3 , pp. 695-711 . https://doi.org/10.1002/jcb.21224 | - |
dc.identifier.issn | 0730-2312 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/6772 | - |
dc.description.abstract | Periostin is predominantly expressed in collagen-rich fibrous connective tissues that are subjected to constant mechanical stresses including: heart valves, tendons, perichondrium, cornea, and the periodontal ligament (PDL). Based on these data we hypothesize that periostin can regulate collagen I fibrillogenesis and thereby affect the biomechanical properties of connective tissues. Immunoprecipitation and immunogold transmission electron microscopy experiments demonstrate that periostin is capable of directly interacting with collagen I. To analyze the potential role of periostin in collagen I fibrillogenesis, gene targeted mice were generated. Transmission electron microscopy and morphometric analyses demonstrated reduced collagen fibril diameters in skin dermis of periostin knockout mice, an indication of aberrant collagen I fibrillogenesis. In addition, differential scanning calorimetry (DSC) demonstrated a lower collagen denaturing temperature in periostin knockout mice, reflecting a reduced level of collagen cross-linking. Functional biomechanical properties of periostin null skin specimens and atrioventricular (AV) valve explant experiments provided direct evidence of the role that periostin plays in regulating the viscoelastic properties of connective tissues. Collectively, these data demonstrate for the first time that periostin can regulate collagen I fibrillogenesis and thereby serves as an important mediator of the biomechanical properties of fibrous connective tissues. | en |
dc.format.extent | 17 | - |
dc.format.extent | 2522220 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Journal of Cellular Biochemistry | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Collagen | - |
dc.subject | Connective tissues | - |
dc.subject | Fasciclin | - |
dc.subject | Fibrillogenesis | - |
dc.subject | Periostin | - |
dc.subject | 1.6 Biological sciences | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Biochemistry | - |
dc.subject | Molecular Biology | - |
dc.subject | Cell Biology | - |
dc.title | Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1002/jcb.21224 | - |
dc.contributor.institution | Rīga Stradiņš University | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=34247882685&partnerID=8YFLogxK | - |
dc.identifier.url | http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3393091&blobtype=pdf | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Periostin.pdf | 2.46 MB | Adobe PDF | View/Open |
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