Please use this identifier to cite or link to this item:
10.2478/prolas-2021-0015
Title: | Significance of hypouricaemia in the development of neurodegenerative diseases |
Authors: | Trapp, Maximiliane Mihailova, Anna Kakurina, Natalija Murovska, Modra Faculty of Medicine Institute of Microbiology and Virology |
Keywords: | uric acid, Alzheimer’s disease, vascular dementia;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database |
Issue Date: | 1-Apr-2021 |
Citation: | Trapp , M , Mihailova , A , Kakurina , N & Murovska , M 2021 , ' Significance of hypouricaemia in the development of neurodegenerative diseases ' , Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences , vol. 75 , no. 2 , pp. 92-98 . https://doi.org/10.2478/prolas-2021-0015 |
Abstract: | Hypouricaemia has received relatively little attention in the literature. As a result, there is lessawareness or understanding of the potential risks of low uric acid levels. Emerging research indi-cates that normal uric acid levels may have an antioxidative and neuroprotective effect. Thisstudy aims to investigate possible associations between hypouricaemia and neurodegenerativedisease. Data was collected from seventy-seven outpatients and inpatients who underwent rou-tine uric acid testing, who were then stratified into patients with and without neurodegenerativedisease. Patients with renal pathologies and patients using uric acid altering medications were ex-cluded from the study. There was a significant difference in the prevalence of Alzheimer’s diseasebetween hypouricemic and normouricemic patients (p= 0.001), however there was no differencein the prevalence of vascular dementia (p= 0.45). This study provides evidence that hypouricae-mia has potential effects on health, specifically on the rate of neurodegenerative diseases suchas Alzheimer’s disease and gives weight to the potential neuroprotective role of uric acid. |
Description: | Publisher Copyright: © 2021 Sciendo. All rights reserved. |
DOI: | 10.2478/prolas-2021-0015 |
ISSN: | 2255-890X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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