Please use this identifier to cite or link to this item:
10.1155/2021/7493190
Title: | Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats |
Authors: | Kuka, Janis Makrecka-Kuka, Marina Vilks, Karlis Korzh, Stanislava Cirule, Helena Sevostjanovs, Eduards Grinberga, Solveiga Dambrova, Maija Liepinsh, Edgars Faculty of Pharmacy |
Keywords: | 1.4 Chemical sciences;3.1 Basic medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Biochemistry;Ageing;Cell Biology |
Issue Date: | 29-Jul-2021 |
Citation: | Kuka , J , Makrecka-Kuka , M , Vilks , K , Korzh , S , Cirule , H , Sevostjanovs , E , Grinberga , S , Dambrova , M & Liepinsh , E 2021 , ' Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats ' , Oxidative Medicine and Cellular Longevity , vol. 2021 , 7493190 . https://doi.org/10.1155/2021/7493190 |
Abstract: | Long-chain ω-3 polyunsaturated fatty acids (PUFAs) are known to induce cardiometabolic benefits, but the metabolic pathways of their biosynthesis ensuring sufficient bioavailability require further investigation. Here, we show that a pharmacological decrease in overall fatty acid utilization promotes an increase in the levels of PUFAs and attenuates cardiometabolic disturbances in a Zucker rat metabolic syndrome model. Metabolome analysis showed that inhibition of fatty acid utilization by methyl-GBB increased the concentration of PUFAs but not the total fatty acid levels in plasma. Insulin sensitivity was improved, and the plasma insulin concentration was decreased. Overall, pharmacological modulation of fatty acid handling preserved cardiac glucose and pyruvate oxidation, protected mitochondrial functionality by decreasing long-chain acylcarnitine levels, and decreased myocardial infarct size twofold. Our work shows that partial pharmacological inhibition of fatty acid oxidation is a novel approach to selectively increase the levels of PUFAs and modulate lipid handling to prevent cardiometabolic disturbances. |
Description: | Publisher Copyright: © 2021 Janis Kuka et al. |
DOI: | 10.1155/2021/7493190 |
ISSN: | 1942-0900 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
---|---|---|---|
Inhibition_of_Fatty_Acid_Metabolism_Increases_EPA.pdf | 1.75 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.