Please use this identifier to cite or link to this item: 10.1155/2021/7493190
Title: Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats
Authors: Kuka, Janis
Makrecka-Kuka, Marina
Vilks, Karlis
Korzh, Stanislava
Cirule, Helena
Sevostjanovs, Eduards
Grinberga, Solveiga
Dambrova, Maija
Liepinsh, Edgars
Faculty of Pharmacy
Keywords: 1.4 Chemical sciences;3.1 Basic medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Biochemistry;Ageing;Cell Biology
Issue Date: 29-Jul-2021
Citation: Kuka , J , Makrecka-Kuka , M , Vilks , K , Korzh , S , Cirule , H , Sevostjanovs , E , Grinberga , S , Dambrova , M & Liepinsh , E 2021 , ' Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats ' , Oxidative Medicine and Cellular Longevity , vol. 2021 , 7493190 . https://doi.org/10.1155/2021/7493190
Abstract: Long-chain ω-3 polyunsaturated fatty acids (PUFAs) are known to induce cardiometabolic benefits, but the metabolic pathways of their biosynthesis ensuring sufficient bioavailability require further investigation. Here, we show that a pharmacological decrease in overall fatty acid utilization promotes an increase in the levels of PUFAs and attenuates cardiometabolic disturbances in a Zucker rat metabolic syndrome model. Metabolome analysis showed that inhibition of fatty acid utilization by methyl-GBB increased the concentration of PUFAs but not the total fatty acid levels in plasma. Insulin sensitivity was improved, and the plasma insulin concentration was decreased. Overall, pharmacological modulation of fatty acid handling preserved cardiac glucose and pyruvate oxidation, protected mitochondrial functionality by decreasing long-chain acylcarnitine levels, and decreased myocardial infarct size twofold. Our work shows that partial pharmacological inhibition of fatty acid oxidation is a novel approach to selectively increase the levels of PUFAs and modulate lipid handling to prevent cardiometabolic disturbances.
Description: Publisher Copyright: © 2021 Janis Kuka et al.
DOI: 10.1155/2021/7493190
ISSN: 1942-0900
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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