Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats

Simple item page
dc.contributor.authorKuka, Janis
dc.contributor.authorMakrecka-Kuka, Marina
dc.contributor.authorVilks, Karlis
dc.contributor.authorKorzh, Stanislava
dc.contributor.authorCirule, Helena
dc.contributor.authorSevostjanovs, Eduards
dc.contributor.authorGrinberga, Solveiga
dc.contributor.authorDambrova, Maija
dc.contributor.authorLiepinsh, Edgars
dc.contributor.institutionFaculty of Pharmacy
dc.date.accessioned2021-10-20T11:05:01Z
dc.date.available2021-10-20T11:05:01Z
dc.date.issued2021-07-29
dc.descriptionPublisher Copyright: © 2021 Janis Kuka et al.
dc.description.abstractLong-chain ω-3 polyunsaturated fatty acids (PUFAs) are known to induce cardiometabolic benefits, but the metabolic pathways of their biosynthesis ensuring sufficient bioavailability require further investigation. Here, we show that a pharmacological decrease in overall fatty acid utilization promotes an increase in the levels of PUFAs and attenuates cardiometabolic disturbances in a Zucker rat metabolic syndrome model. Metabolome analysis showed that inhibition of fatty acid utilization by methyl-GBB increased the concentration of PUFAs but not the total fatty acid levels in plasma. Insulin sensitivity was improved, and the plasma insulin concentration was decreased. Overall, pharmacological modulation of fatty acid handling preserved cardiac glucose and pyruvate oxidation, protected mitochondrial functionality by decreasing long-chain acylcarnitine levels, and decreased myocardial infarct size twofold. Our work shows that partial pharmacological inhibition of fatty acid oxidation is a novel approach to selectively increase the levels of PUFAs and modulate lipid handling to prevent cardiometabolic disturbances.en
dc.description.statusPeer reviewed
dc.format.extent13
dc.format.extent1794802
dc.identifier.citationKuka, J, Makrecka-Kuka, M, Vilks, K, Korzh, S, Cirule, H, Sevostjanovs, E, Grinberga, S, Dambrova, M & Liepinsh, E 2021, 'Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats', Oxidative Medicine and Cellular Longevity, vol. 2021, 7493190. https://doi.org/10.1155/2021/7493190
dc.identifier.doi10.1155/2021/7493190
dc.identifier.issn1942-0900
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6682
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85112258746&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofOxidative Medicine and Cellular Longevity
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject1.4 Chemical sciences
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectBiochemistry
dc.subjectAgeing
dc.subjectCell Biology
dc.titleInhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Ratsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Inhibition_of_Fatty_Acid_Metabolism_Increases_EPA.pdf
Size:
1.71 MB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure