Please use this identifier to cite or link to this item:
10.3390/biomedicines9091216
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DC Field | Value | Language |
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dc.contributor.author | Jain, Nityanand | - |
dc.contributor.author | Smirnovs, Marks | - |
dc.contributor.author | Strojeva, Samanta | - |
dc.contributor.author | Murovska, Modra | - |
dc.contributor.author | Skuja, Sandra | - |
dc.date.accessioned | 2021-10-14T13:15:01Z | - |
dc.date.available | 2021-10-14T13:15:01Z | - |
dc.date.issued | 2021-09-01 | - |
dc.identifier.citation | Jain , N , Smirnovs , M , Strojeva , S , Murovska , M & Skuja , S 2021 , ' Chronic Alcoholism and HHV-6 Infection Synergistically Promote Neuroinflammatory Microglial Phenotypes in the Substantia Nigra of the Adult Human Brain ' , Biomedicines , vol. 9 , no. 9 , 1216 . https://doi.org/10.3390/biomedicines9091216 , https://doi.org/10.3390/biomedicines9091216 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.other | PubMedCentral: PMC8472392 | - |
dc.identifier.other | Mendeley: f37b22ab-572b-3da0-b3b3-a67e5afb4ae4 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/6651 | - |
dc.description | Funding Information: Funding: The present study was funded by Fundamental & Applied Research Projects (FLPP), Latvian Council of Science wide no. lzp-2020/2-0069 (The role of human herpesvirus-6 infection and alcohol abuse in the development of neuroinflammation). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.description.abstract | Both chronic alcoholism and human herpesvirus-6 (HHV-6) infection have been identified as promoters of neuroinflammation and known to cause movement-related disorders. Substantia Nigra (SN), the dopaminergic neuron-rich region of the basal ganglia, is involved in regulating motor function and the reward system. Hence, we hypothesize the presence of possible synergism between alcoholism and HHV-6 infection in the SN region and report a comprehensive quantification and characterization of microglial functions and morphology in postmortem brain tissue from 44 healthy, age-matched alcoholics and chronic alcoholics. A decrease in the perivascular CD68+ microglia in alcoholics was noted in both the gray and white matter. Additionally, the CD68+/Iba1- microglial subpopulation was found to be the dominant type in the controls. Conversely, in alcoholics, dystrophic changes in microglia were seen with a significant increase in Iba1 expression and perivascular to diffuse migration. An increase in CD11b expression was noted in alcoholics, with the Iba1+/CD11b- subtype promoting inflammation. All the controls were found to be negative for HHV-6 whilst the alcoholics demonstrated HHV-6 positivity in both gray and white matter. Amongst HHV-6 positive alcoholics, all the above-mentioned changes were found to be heightened when compared with HHV-6 negative alcoholics, thereby highlighting the compounding relationship between alcoholism and HHV-6 infection that promotes microglia-mediated neuroinflammation. | en |
dc.format.extent | 117577517 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Biomedicines | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Chronic alcoholism | - |
dc.subject | HHV-6 | - |
dc.subject | Microglia | - |
dc.subject | Neuroinflammation | - |
dc.subject | Substantia Nigra | - |
dc.subject | 3.3 Health sciences | - |
dc.subject | 5.1 Psychology | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Medicine (miscellaneous) | - |
dc.subject | General Biochemistry,Genetics and Molecular Biology | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Chronic Alcoholism and HHV-6 Infection Synergistically Promote Neuroinflammatory Microglial Phenotypes in the Substantia Nigra of the Adult Human Brain | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/biomedicines9091216 | - |
dc.contributor.institution | Joint Laboratory of Electron Microscopy | - |
dc.contributor.institution | Institute of Microbiology and Virology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85115254510&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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