Please use this identifier to cite or link to this item:
10.1186/s12876-021-01939-7
Title: | Intriguing findings of liver fibrosis following COVID-19 |
Authors: | Koļesova, Oksana Vanaga, Ieva Laivacuma, Sniedze Derovs, Aleksejs Koļesovs, Aleksandrs Radzina, Maija Platkājis, Ardis Eglīte, Jeļena Hagina, Elvīra Arutjuņana, Seda Putriņš, Dāvis Sīmanis Storoženko, Jeļena Rozentāle, Baiba Vīksna, Ludmila Joint Laboratory of Clinical Immunology and Immunogenetics Department of Infectology Department of Radiology Department of Public Health and Epidemiology |
Keywords: | Covid-19;Liver fibrosis index;Consequences;Hyaluronic acid;Serological biomarker;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database |
Issue Date: | Dec-2021 |
Citation: | Koļesova , O , Vanaga , I , Laivacuma , S , Derovs , A , Koļesovs , A , Radzina , M , Platkājis , A , Eglīte , J , Hagina , E , Arutjuņana , S , Putriņš , D S , Storoženko , J , Rozentāle , B & Vīksna , L 2021 , ' Intriguing findings of liver fibrosis following COVID-19 ' , BMC Gastroenterology , vol. 21 , no. 1 , 370 . https://doi.org/10.1186/s12876-021-01939-7 |
Abstract: | Background: Studies on a new coronavirus disease (COVID-19) show the elevation of liver enzymes and liver fibrosis index (FIB-4) independently on pre-existing liver diseases. It points to increased liver fibrogenesis during acute COVID-19 with possible long-term consequences. This study aimed to assess liver fibrosis in COVID-19 patients by serum hyaluronic acid (HA) and FIB-4. Methods: The study included the acute COVID-19 group (66 patients, 50% females, mean age 58.3 ± 14.6), the post-COVID group (58 patients in 3–6 months after the recovery, 47% females, mean age 41.2 ± 13.4), and a control group (17 people, 47% females, mean age 42.8 ± 11.0). Ultrasound elastography was performed in the post-COVID and control groups. Results: Sixty-five percent of the acute COVID-19 group had increased FIB-4 (> 1.45), and 38% of patients had FIB-4 ≥ 3.25. After matching by demographics, 52% of acute COVID-19 and 5% of the post-COVID group had FIB-4 > 1.45, and 29% and 2% of patients had FIB-4 ≥ 3.25, respectively. Increased serum HA (≥ 75 ng/ml) was observed in 54% of the acute COVID-19 and 15% of the post-COVID group. In the acute COVID-19 group, HA positively correlated with FIB-4, AST, ALT, LDH, IL-6, and ferritin and negatively with blood oxygen saturation. In the post-COVID group, HA did not correlate with FIB-4, but it was positively associated with higher liver stiffness and ALT. Conclusion: More than half of acute COVID-19 patients had increased serum HA and FIB-4 related to liver function tests, inflammatory markers, and blood oxygen saturation. It provides evidence for the induction of liver fibrosis by multiple factors during acute COVID-19. Findings also indicate possible liver fibrosis in about 5% of the post-COVID group. |
Description: | Funding Information: The authors would like to thank the Boris and Inara Teterev Foundation, R?ga Stradi?? University, and Riga East Clinical University Hospital for organizational support. Funding Information: The study was funded by the Ministry of Education and Science of the, Republic of Latvia, project “Clinical, biochemical, immunogenetic paradigms of Covid-19 infection and their correlation with socio-demographic, etiological, pathogenetic, diagnostic, therapeutically and prognostically important factors to be included in guidelines”, project No. VPP-COVID-2020/1-0023. Publisher Copyright: © 2021, The Author(s). |
DOI: | 10.1186/s12876-021-01939-7 |
ISSN: | 1471-230X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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