Please use this identifier to cite or link to this item:
10.1053/euhj.2001.3158
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DC Field | Value | Language |
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dc.contributor.author | Moiseyev, V. S. | - |
dc.contributor.author | Põder, P. | - |
dc.contributor.author | Andrejevs, N. | - |
dc.contributor.author | Ruda, M. Y. | - |
dc.contributor.author | Golikov, A. P. | - |
dc.contributor.author | Lazebnik, L. B. | - |
dc.contributor.author | Kobalava, Z. D. | - |
dc.contributor.author | Lehtonen, L. A. | - |
dc.contributor.author | Laine, T. | - |
dc.contributor.author | Nieminen, Markku S. | - |
dc.contributor.author | Lie, K. I. | - |
dc.date.accessioned | 2021-10-01T12:45:01Z | - |
dc.date.available | 2021-10-01T12:45:01Z | - |
dc.date.issued | 2002-09 | - |
dc.identifier.citation | Moiseyev , V S , Põder , P , Andrejevs , N , Ruda , M Y , Golikov , A P , Lazebnik , L B , Kobalava , Z D , Lehtonen , L A , Laine , T , Nieminen , M S & Lie , K I 2002 , ' Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction : A randomized, placebo-controlled, double-blind study (RUSSLAN) ' , European Heart Journal , vol. 23 , no. 18 , pp. 1422-1432 . https://doi.org/10.1053/euhj.2001.3158 | - |
dc.identifier.issn | 0195-668X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/6487 | - |
dc.description.abstract | Aims: To evaluate the safety and efficacy of levosimendan in patients with left ventricular failure complicating acute myocardial infarction. Methods and Results: Levosimendan at different doses (0·1-0·4 μg . kg-1 . min-1) or placebo were administered intravenously for 6 h to 504 patients in a randomised, placebo-controlled, double-blind study. The primary end-point was hypotension or myocardial ischaemia of clinical significance adjudicated by an independent Safety Committee. Secondary end-points included risk of death and worsening heart failure, symptoms of heart failure and all-cause mortality. The incidence of ischaemia and/or hypotension was similar in all treatment groups (P=0·319). A higher frequency of ischaemia and/or hypotension was only seen in the highest levosimendan dose group. Levosimendan-treated patients experienced lower risk of death and worsening heart failure than patients receiving placebo, during both the 6h infusion (2·0% vs 5·9%; P=0·033) and over 24 h (4·0% vs 8·8%; P=0·044). Mortality was lower with levosimendan compared with placebo at 14 days (11·7% vs 19·6%; hazard ratio 0·56 [95% CI 0·33-0·951; P=0·031) and the reduction was maintained at the 180-day retrospective follow-up (22·6% vs 31·4%; 0·67 [0·45-1·00], P=0·053). Conclusions: Levosimendan at doses 0·1-0·2 μg . kg-1 . min-1 did not induce hypotension or ischaemia and reduced the risk of worsening heart failure and death in patients with left ventricular failure complicating acute myocardial infarction. | en |
dc.format.extent | 11 | - |
dc.format.extent | 173047 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | European Heart Journal | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Hypotension | - |
dc.subject | Ischaemia | - |
dc.subject | Left ventricular failure | - |
dc.subject | Levosimendan | - |
dc.subject | Mortality | - |
dc.subject | Myocardial infarction | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Cardiology and Cardiovascular Medicine | - |
dc.title | Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction : A randomized, placebo-controlled, double-blind study (RUSSLAN) | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1053/euhj.2001.3158 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=0036764821&partnerID=8YFLogxK | - |
dc.identifier.url | https://academic.oup.com/eurheartj/article/23/18/1422/490755 | - |
dc.identifier.url | https://academic.oup.com/eurheartj/article/23/18/1422/490755 | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Safety.pdf | 168.99 kB | Adobe PDF | View/Open |
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