Please use this identifier to cite or link to this item:
10.3390/cancers13133345
Title: | Blood Arsenic Levels as a Marker of Breast Cancer Risk among BRCA1 Carriers |
Authors: | Marciniak, Wojciech Matousek, Tomas Domchek, Susan Paradiso, Angelo Patruno, Margherita Irmejs, Arvīds Roderte, Irita Derkacz, Roza Baszuk, Piotr Kuswik, Magdalena Cybulski, Cezary Huzarski, Tomasz Gronwald, Jacek Debniak, Tadeusz Falco, Michal Lener, Marcin R. Jakubowska, Anna Pullella, Katherine Kotsopoulos, Joanne Narod, Steven Lubinski, Jan Department of Surgery RSU Institute of Oncology |
Keywords: | blood arsenic;cancer risk;epidemiology;BRCA1 carriers;prospective cohort;breast cancer;3.2 Clinical medicine;3.1 Basic medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;SDG 3 - Good Health and Well-being |
Issue Date: | 3-Jul-2021 |
Citation: | Marciniak , W , Matousek , T , Domchek , S , Paradiso , A , Patruno , M , Irmejs , A , Roderte , I , Derkacz , R , Baszuk , P , Kuswik , M , Cybulski , C , Huzarski , T , Gronwald , J , Debniak , T , Falco , M , Lener , M R , Jakubowska , A , Pullella , K , Kotsopoulos , J , Narod , S & Lubinski , J 2021 , ' Blood Arsenic Levels as a Marker of Breast Cancer Risk among BRCA1 Carriers ' , Cancers , vol. 13 , no. 13 , 3345 . https://doi.org/10.3390/cancers13133345 |
Abstract: | An important group of breast cancers is those associated with inherited susceptibility. In women, several predisposing mutations in genes involved in DNA repair have been discovered. Women with a germline pathogenic variant in BRCA1 have a lifetime cancer risk of 70%. As part of a larger prospective study on heavy metals, our aim was to investigate if blood arsenic levels are associated with breast cancer risk among women with inherited BRCA1 mutations. A total of 1084 participants with pathogenic variants in BRCA1 were enrolled in this study. Subjects were followed from 2011 to 2020 (mean follow-up time: 3.75 years). During that time, 90 cancers were diagnosed, including 67 breast and 10 ovarian cancers. The group was stratified into two categories (lower and higher blood As levels), divided at the median (<0.85 µg/L and ≥0.85 µg/L) As level among all unaffected participants. Cox proportional hazards models were used to model the association between As levels and cancer incidence. A high blood As level (≥0.85 µg/L) was associated with a significantly increased risk of developing breast cancer (HR = 2.05; 95%CI: 1.18–3.56; p = 0.01) and of any cancer (HR = 1.73; 95%CI: 1.09–2.74; p = 0.02). These findings suggest a possible role of environmental arsenic in the development of cancers among women with germline pathogenic variants in BRCA1. |
Description: | Funding Information: Funding: The study was funded by the National Centre for Research and Development Projects. INNOMED/1/16/NCBR/2014 and PBS3/B7/26/2015. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
DOI: | 10.3390/cancers13133345 |
ISSN: | 2072-6694 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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