Please use this identifier to cite or link to this item:
10.2478/prolas-2018-0028
Title: | Non-invasive diagnosis of gastroesophageal reflux disease using gastrin- and pepsinogen-based tests |
Authors: | Moisejevs, Georgijs Daugule, Ilva Isajevs, Sergejs Rudzite, Dace Janciauskas, Dainius Tolmanis, Ivars Leja, Marcis Scientific Laboratory of Molecular Genetics Department of Internal Diseases |
Keywords: | Gastroesophageal reflux disease;Gastrin-17;Pepsinogen-1;Pepsinogen-2;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database |
Issue Date: | 2018 |
Citation: | Moisejevs , G , Daugule , I , Isajevs , S , Rudzite , D , Janciauskas , D , Tolmanis , I & Leja , M 2018 , ' Non-invasive diagnosis of gastroesophageal reflux disease using gastrin- and pepsinogen-based tests ' , Proceedings of the Latvian Academy of Sciences. , vol. 72 , no. 3 , pp. 172-176 . https://doi.org/10.2478/prolas-2018-0028 |
Abstract: | Gastrin-17 (G-17), pepsinogen-1 (Pg1) and pepsinogen-2 (Pg2) reflect the functional state of gas-tric mucosa and are used for non-invasive diagnosis and screening of atrophic gastritis. The aimof the study was to clarify if erosive reflux disease (ERD) or non-ERD (NERD) can be distin-guished from other dyspeptic conditions in patients, in a non-invasive manner using specificbiomarkers. Levels of G-17, Pg1, and Pg2 were measured in 141 ERD patients (median age 48years, males — 68), 122 NERD patients (median age 45 years, males — 32) and 410 control pa-tients (median age 50 years, males — 97). Levels of biomarkers in ERD and NERD groups werecompared to controls. Median levels of G-17 (1.94 vs 2.92 pmol/L, p = 0.036) and Pg2 (6.70 vs7.79 μg/l,p= 0.046) were lower in the ERD group compared to control patients; no differencewith respect to the control was found for the NERD group. After exclusion of the patients havingat least one potential condition that might modify the levels of the biomarkers (gastric mucosa at-rophy, Helicobacter pylori colonisation), no difference in levels of biomarkers was observed withrespect to the control for both the ERD and NERD groups. G-17, Pg1, and Pg2 based tests can-not be used to distinguish ERD or NERD from other dyspeptic conditions in patients. |
DOI: | 10.2478/prolas-2018-0028 |
ISSN: | 1407-009X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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NON_INVASIVE_DIAGNOSIS_OF_GASTROESOPHAGEAL_REFLUX.pdf | 146.81 kB | Adobe PDF | View/Open |
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