Please use this identifier to cite or link to this item: 10.3390/pathogens9100826
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dc.contributor.authorFridmanis, Jēkabs-
dc.contributor.authorBobrovs, Raitis-
dc.contributor.authorBrangulis, Kalvis-
dc.contributor.authorTārs, Kaspars-
dc.contributor.authorJaudzems, Kristaps-
dc.date.accessioned2021-09-08T08:50:01Z-
dc.date.available2021-09-08T08:50:01Z-
dc.date.issued2020-10-
dc.identifier.citationFridmanis , J , Bobrovs , R , Brangulis , K , Tārs , K & Jaudzems , K 2020 , ' Structural and functional analysis of bba03, borrelia burgdorferi competitive advantage promoting outer surface lipoprotein ' , Pathogens , vol. 9 , no. 10 , 826 , pp. 1-13 . https://doi.org/10.3390/pathogens9100826-
dc.identifier.issn2076-0817-
dc.identifier.otherunpaywall: 10.3390/pathogens9100826-
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6240-
dc.descriptionPublisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.-
dc.description.abstractBBA03 is a Borrelia burgdorferi outer surface lipoprotein encoded on one of the most conserved plasmids in Borrelia genome, linear plasmid 54 (lp54). Although many of its genes have been identified as contributing or essential for spirochete fitness in vivo, the majority of the proteins encoded on this plasmid have no known function and lack homologs in other organisms. In this paper, we report the solution NMR structure of the B. burgdorferi outer surface lipoprotein BBA03, which is known to provide a competitive advantage to the bacteria during the transmission from tick vector to mammalian host. BBA03 shows structural homology to other outer surface lipoproteins reflecting their genetic and evolutionary relatedness. Analysis of the structure reveals a pore in BBA03, which could potentially bind lipids.en
dc.format.extent13-
dc.format.extent2399855-
dc.language.isoeng-
dc.relation.ispartofPathogens-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.subjectBBA03-
dc.subjectCompetitive advantage-
dc.subjectLp54-
dc.subjectPfam54-
dc.subjectSolution NMR structure-
dc.subject3.1 Basic medicine-
dc.subject1.6 Biological sciences-
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database-
dc.subjectImmunology and Allergy-
dc.subjectMolecular Biology-
dc.subjectGeneral Immunology and Microbiology-
dc.subjectMicrobiology (medical)-
dc.subjectInfectious Diseases-
dc.subjectSDG 3 - Good Health and Well-being-
dc.titleStructural and functional analysis of bba03, borrelia burgdorferi competitive advantage promoting outer surface lipoproteinen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article-
dc.identifier.doi10.3390/pathogens9100826-
dc.contributor.institutionDepartment of Human Physiology and Biochemistry-
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85092483723&partnerID=8YFLogxK-
dc.description.statusPeer reviewed-
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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