Please use this identifier to cite or link to this item: 10.3390/medicina44010003
Title: Natural clearance of hepatitis C virus in hemophilia patients
Authors: Simanis, Raimonds
Lejniece, Sandra
Sochnevs, Arturs
Eglite, Jelena
Chernevska, Gunta
Kovalova, Zhanna
Gardovska, Dace
Jeruma, Agita
Kuse, Velga
Viksna, Ludmila
Department of Infectology
Department of Internal Diseases
Joint Laboratory of Clinical Immunology and Immunogenetics
Department of Paediatrics
Keywords: Hemophilia;Hepatitis C virus;Human leukocyte antigen;Natural clearance;3.3 Health sciences;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Medicine;SDG 3 - Good Health and Well-being
Issue Date: 2008
Citation: Simanis , R , Lejniece , S , Sochnevs , A , Eglite , J , Chernevska , G , Kovalova , Z , Gardovska , D , Jeruma , A , Kuse , V & Viksna , L 2008 , ' Natural clearance of hepatitis C virus in hemophilia patients ' , Medicina , vol. 44 , no. 1 , pp. 15-21 . https://doi.org/10.3390/medicina44010003
Abstract: Objective. The objective of this study was to investigate the prevalence of HCV (hepatitis C virus) infection in hemophilia patients in Latvia and to analyze association between natural clearance of HCV and human leukocyte antigen (HLA) class II genes. Material and methods. From 61 hemophilic patients participating in this study, 38 were adults and 23 were pediatric patients younger than 18 years. To analyze association between HLA class II alleles and natural clearance of HCV, the gene frequency was compared in hemophilia patients group and the control group of 60 healthy subjects, all men. Serum HCV RNA was qualitatively determined and HLA class II alleles were identified by polymerase chain reaction (PCR) method. Results. HCV infection is common among hemophilia patients in Latvia. Antibodies to HCV were found in 45 of 61 (74%) hemophilia patients. In 41% of hemophilia patients (18 of 44), HCV infection resolved spontaneously. Children cleared HCV more frequently than adults (7 of 11 comparing to 11 of 33, respectively; OR=3.50; P<0.05). The frequency difference was found to be statistically significant when comparing HLA alleles distribution in the sample of hemophilia patients who naturally cleared HCV (n=18) and in the control group (n=60) (corresponding frequency of HLA-DRB1*07 allele - 4 (11.11%) and 9 (1.67%); OR=7.38; P<0.05). Conclusions. Natural clearance of HCV infection is frequently found in hemophilia patients in Latvia. Children are more likely to clear virus naturally than adults. There is an association between natural clearance of HCV and HLA allele DRB1*07 in hemophilia patients.
Description: Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
DOI: 10.3390/medicina44010003
ISSN: 1010-660X
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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