Natural clearance of hepatitis C virus in hemophilia patients

Simple item page
dc.contributor.authorSimanis, Raimonds
dc.contributor.authorLejniece, Sandra
dc.contributor.authorSochnevs, Arturs
dc.contributor.authorEglite, Jelena
dc.contributor.authorChernevska, Gunta
dc.contributor.authorKovalova, Zhanna
dc.contributor.authorGardovska, Dace
dc.contributor.authorJeruma, Agita
dc.contributor.authorKuse, Velga
dc.contributor.authorViksna, Ludmila
dc.contributor.institutionDepartment of Infectology
dc.contributor.institutionDepartment of Internal Diseases
dc.contributor.institutionKlīniskās imunoloģijas un imunoģenētikas starpkatedru laboratorija
dc.contributor.institutionDepartment of Paediatrics
dc.date.accessioned2021-09-07T07:25:01Z
dc.date.available2021-09-07T07:25:01Z
dc.date.issued2008
dc.descriptionCopyright: Copyright 2020 Elsevier B.V., All rights reserved.
dc.description.abstractObjective. The objective of this study was to investigate the prevalence of HCV (hepatitis C virus) infection in hemophilia patients in Latvia and to analyze association between natural clearance of HCV and human leukocyte antigen (HLA) class II genes. Material and methods. From 61 hemophilic patients participating in this study, 38 were adults and 23 were pediatric patients younger than 18 years. To analyze association between HLA class II alleles and natural clearance of HCV, the gene frequency was compared in hemophilia patients group and the control group of 60 healthy subjects, all men. Serum HCV RNA was qualitatively determined and HLA class II alleles were identified by polymerase chain reaction (PCR) method. Results. HCV infection is common among hemophilia patients in Latvia. Antibodies to HCV were found in 45 of 61 (74%) hemophilia patients. In 41% of hemophilia patients (18 of 44), HCV infection resolved spontaneously. Children cleared HCV more frequently than adults (7 of 11 comparing to 11 of 33, respectively; OR=3.50; P<0.05). The frequency difference was found to be statistically significant when comparing HLA alleles distribution in the sample of hemophilia patients who naturally cleared HCV (n=18) and in the control group (n=60) (corresponding frequency of HLA-DRB1*07 allele - 4 (11.11%) and 9 (1.67%); OR=7.38; P<0.05). Conclusions. Natural clearance of HCV infection is frequently found in hemophilia patients in Latvia. Children are more likely to clear virus naturally than adults. There is an association between natural clearance of HCV and HLA allele DRB1*07 in hemophilia patients.en
dc.description.statusPeer reviewed
dc.format.extent7
dc.format.extent192568
dc.identifier.citationSimanis, R, Lejniece, S, Sochnevs, A, Eglite, J, Chernevska, G, Kovalova, Z, Gardovska, D, Jeruma, A, Kuse, V & Viksna, L 2008, 'Natural clearance of hepatitis C virus in hemophilia patients', Medicina, vol. 44, no. 1, pp. 15-21. https://doi.org/10.3390/medicina44010003
dc.identifier.doi10.3390/medicina44010003
dc.identifier.issn1010-660X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6204
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=40949101416&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHemophilia
dc.subjectHepatitis C virus
dc.subjectHuman leukocyte antigen
dc.subjectNatural clearance
dc.subject3.3 Health sciences
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleNatural clearance of hepatitis C virus in hemophilia patientsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Natural_clearance_of_hepatitis_C_virus_in_hemophilia_patients.pdf
Size:
188.05 KB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure