Please use this identifier to cite or link to this item:
10.32471/exp-oncology.2312-8852.vol-42-no-1.14147
Title: | Survival analysis of oropharyngeal squamous cell carcinoma patients linked to histopathology, disease stage, tumor stage, risk factors, and received therapy |
Authors: | Lifsics, A. Rate, E. Ivanova, A. Tars, J. Murovska, M. Groma, V. Department of Otorhinolaryngology Institute of Microbiology and Virology Institute of Anatomy and Anthropology |
Keywords: | Oropharyngeal squamous cell carcinoma;Risk factors;Survival rates;3.2 Clinical medicine;1.6 Biological sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;Oncology;Cancer Research;SDG 3 - Good Health and Well-being |
Issue Date: | Mar-2020 |
Citation: | Lifsics , A , Rate , E , Ivanova , A , Tars , J , Murovska , M & Groma , V 2020 , ' Survival analysis of oropharyngeal squamous cell carcinoma patients linked to histopathology, disease stage, tumor stage, risk factors, and received therapy ' , Experimental Oncology , vol. 42 , no. 1 , pp. 51-59 . https://doi.org/10.32471/exp-oncology.2312-8852.vol-42-no-1.14147 |
Abstract: | Background: Survival of oropharyngeal squamous cell carcinoma (OSCC) patients depends on the risk and environmental factors, tumor biology, achievements in diagnostics and treatment approaches. Aim: To perform a survival analysis of the patients with OSCC treated over a 10-year period in a single hospital in Latvia linking these data to histopathological findings, risk factors and received therapy. Materials and Methods: The main outcome measures were overall and disease-specific survival (OS and DS) along with histopathology analysis. Results: Kaplan - Meier survival analysis showed better survival for females, younger patients lacking bad habits, operated and received radiotherapy, with lower T grade and disease stage. Cox regression showed diminished early death risk in patients with lower T grade, no regional metastases (N0) and bad habits, operated and received radiotherapy. A vast majority of tumors were localized in palatine tonsils and the base of the tongue. The localization did not correlate with mean survival time/survival. Lower OS (p = 0.03) and DS (p = 0.026) were estimated for patients with pharyngeal wall and tonsillar involvement compared to tumors localized in the soft palate. A histological variant of tumor seemed irrelevant estimating OS and DS, whereas therapeutic modalities significantly affected survival. Conclusions: OSCC patients with lower T grade, N0 status, lacking bad habits, and surgically treated had better survival. |
Description: | Publisher Copyright: Copyright © Experimental Oncology, 2020. Copyright: Copyright 2020 Elsevier B.V., All rights reserved. |
DOI: | 10.32471/exp-oncology.2312-8852.vol-42-no-1.14147 |
ISSN: | 1812-9269 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Survival_analysis_of_oropharyngeal_squamous_cell.pdf | 406.5 kB | Adobe PDF | View/Open |
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