Please use this identifier to cite or link to this item:
10.1515/prolas-2016-0035
Title: | Antibacterial Efficiency of Hydroxyapatite Biomaterials with Biodegradable Polylactic Acid and Polycaprolactone Polymers Saturated with Antibiotics |
Authors: | Kroiča, Juta Skadiņš, Ingus Salma, Ilze Reinis, Aigars Sokolova, Marina Rostoka, Dagnija Berza, Natalija Department of Biology and Microbiology |
Keywords: | antimicrobial agents;biodegradable polymers.;composite materials;P. aeruginosa;S. epidermidis;2.5 Materials engineering;3.1 Basic medicine;1.6 Biological sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;General |
Issue Date: | 1-Aug-2016 |
Citation: | Kroiča , J , Skadiņš , I , Salma , I , Reinis , A , Sokolova , M , Rostoka , D & Berza , N 2016 , ' Antibacterial Efficiency of Hydroxyapatite Biomaterials with Biodegradable Polylactic Acid and Polycaprolactone Polymers Saturated with Antibiotics ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 70 , no. 4 , pp. 220-226 . https://doi.org/10.1515/prolas-2016-0035 |
Abstract: | Infections continue to spread in all fields of medicine, and especially in the field of implant biomaterial surgery, and not only during the surgery, but also after surgery. Reducing the adhesion of bacteria could decrease the possibility of biomaterial-associated infections. Bacterial adhesion could be reduced by local antibiotic release from the biomaterial. In this in vitro study, hydroxyapatite biomaterials with antibiotics and biodegradable polymers were tested for their ability to reduce bacteria adhesion and biofilm development. This study examined the antibacterial efficiency of hydroxyapatite biomaterials with antibiotics and biodegradable polymers against Staphylococcus epidermidis and Pseudomonas aeruginosa. The study found that hydroxyapatite biomaterials with antibiotics and biodegradable polymers show longer antibacterial properties than hydroxyapatite biomaterials with antibiotics against both bacterial cultures. Therefore, the results of this study demonstrated that biomaterials that are coated with biodegradable polymers release antibiotics from biomaterial samples for a longer period of time and may be useful for reducing bacterial adhesion on orthopedic implants. |
Description: | Publisher Copyright: © 2016 by Ingus Skadiņš. Copyright: Copyright 2016 Elsevier B.V., All rights reserved. |
DOI: | 10.1515/prolas-2016-0035 |
ISSN: | 1407-009X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Antibacterial_efficiency_of_hydroxyapatite_biomaterials.pdf | 507.82 kB | Adobe PDF | View/Open |
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